Open Access Books

Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies.

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Ce livre nous fait revivre le fonctionnement des écoles normales depuis l'époque de leur splendeur jusqu'à la crise actuelle à laquelle la réforme de 1979 n'a pas mis un terme. Mais le propos n'est pas seulement historique. L'auteur aborde ici la question toujours brûlante de la formation des maîtres, qui déborde largement le cadre de la seule école élémentaire.

Ceramic materials in the form of coatings can significantly improve the functionality and applications of other engineering materials. Due to a wide range of controllable features and various deposition methods, it is possible to create tailored substrate–coating systems that meet the requirements of modern technologies. Therefore, it is crucial to understand the relationships between the structures, morphology and the properties of ceramic coatings and expand the base of scientific knowledge about them. This book contains a series of fourteen articles which present research on the production and properties of ceramic coatings designed to improve functionality for advanced applications.

In recent years, there has been a fast growth in the application of long-memory processes to underlying assets including stock, volatility index, exchange rate, etc. The fractional Brownian motion is the most popular of the long-memory processes and was introduced by Kolmogorov in 1940 and later by Mandelbrot in 1965. It has been used in hydrology and climatology as well as finance. The dynamics of the volatility of asset price or asset price itself were modelled as a fractional Brownian motion in finance and are called rough volatility models and the fractional Black–Scholes model, respectively. Fractional diffusion processes are also used to model the dynamics of underlying assets. The option price under the fractional diffusion setting induces fractional partial differential equations involving the fractional derivatives with respect to the time and the space, respectively. Some closed-form solutions might be found via transform methods in some cases of applications, and numerical methods to solve fractional partial differential equations are being developed. This Special Issue focuses on empirical studies as well as option pricing. The empirical studies consist of multifractal analyses of stock market and volatility index. Multifractal analyses include cross-correlation multifractal analysis, multifractal detrended fluctuation analysis, and other fractional analyses. Meanwhile, option pricing focuses on the fractional Black–Scholes models and their variants, including the fuzzy fractional Black–Scholes model, uncertain fractional differential equation, and model with fractional-order feature.

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.

The history of science is referred by several authors as fundamental to the understanding of how science works, useful for the learning processes, and relevant to the promotion of the humanization of science through biographies. Starting from these premises, themes such as biographies of scientists, historical objects, museum collections, historical works and theories, school and dissemination programs, in this work are involved in a dialogue with formal and informal teaching, as well as non-formal teaching, through historical objects and museum collections, historical works, and new educational approaches.

Was aber passiert beim Interpretieren eines Textes? Woran kann sich die wissenschaftliche Interpretation eines Textes orientieren? Wie kann diese Praxis so gestaltet werden, dass ihre Ergebnisse vor einem wissenschaftlichen Publikum vertreten werden können und sie diesem Kreis als respektabel gelten? Zu diesen Fragen gibt es etliche methodologisch explizierte und unüberschaubar viele praktisch vollzogene Antworten. In diesem Buch wird ein nicht zuletzt in der rassismus- und herrschaftskritisch interessierten Analyse gesellschaftlicher Verhältnisse herausgebildeter, interpretativer Forschungsstil vorgestellt. Dies weniger im Sinne einer programmatischen Deklaration, sondern vielmehr in einer umkreisenden, vielstimmigen und perspektivenreichen Weise, die sich dem Forschungsstil in seiner bestimmten Unbestimmtheit, in seinen Verästelungen und Versionen, seinem epistemischen Begehren und dessen Grenzen nähert.

Phylogeny represents the historical pattern of relationships among organisms that have arisen in numerous evolutionary events. Breeding has a proven track record of increasing agricultural productivity with a wide range of technologies. In recent years, due to their commercial importance and increasing demand, research on genetics and the breeding of medicinal plants has gradually increased and made some progress. However, much work remains to be done to explore the functions of genes, regulatory mechanisms, and signaling pathways for stimulating the development of breeding technologies in order to improve traits.

A l'heure du difficile démarrage de l'Europe sociale, ce livre offre des nouvelles clés d'analyse du " modèle social " allemand. Si ce modèle est habituellement référé au régime d'assurances bismarckiennes, ce n'est pas le moindre des paradoxes que l'assurance chômage ait été instituée quarante ans plus tard seulement, au terme d'âpres controverses. L'auteur retrace l'improbable processus de fabrication de cette catégorie nationale des politiques publiques, à partir de l'étude d'une plu­ralité d'expériences locales de traitement du non-travail et des difficultés de leur coordination nationale sous le Kaiserreich et la République de Weimar. La socio-histoire de la catégorie de chômage ainsi esquissée est également celle de la constitution nationale de l'État allemand et de la définition de ses rapports avec les collectifs intermédiaires. Un tel croisement entre le travail et le politique permet, d'une part, de rendre compte des différents types de déplacements qui fondent le changement et autorisent in fine l'avènement d'une nouvelle caté­gorie d'action. Il permet, d'autre part, de mettre en évidence les rapports particuliers au travail et au non-travail, mais également entre salariés, employeurs et instances publiques, qui ont structuré le processus de catégorisation. Ces élé­ments constitutifs, qui n'apparaissent plus nécessairement comme tels une fois la catégorie stabilisée, ont contribué à façonner l'espace social du chômage en Allemagne et à donner sens, jusqu'à nos jours, aux expériences individuelles de non-travail. Par-delà le chômage, c'est tout un pan des fondements du droit du travail allemand contemporain qui se trouve ainsi revisité, en particulier la notion de démocratie sociale et les agencements inédits entre l'économique et le social associés au modèle néo-corporatiste.

This book recognizes the career of Professor Emeritus Calvin H. Bartholomew, who celebrated his 75th birthday in 2018, and his contributions to the science and engineering of heterogeneous catalysis, a field which improves daily life in countless, but often unrecognized ways. Dr. Bartholomew is an eminent researcher, an outstanding educator, mentor, and friend. The nine chapters comprising the book were written by former students, collaborators, colleagues, and respected peers. Chapters cover supported iron Fischer–-Tropsch catalysts, a spectroscopic study of iron-based water gas shift catalysts, nickel catalysts both for (dry) methane reforming with associated carbon deactivation and carbon dioxide methanation, a methanol steam reforming catalyst, cobalt oxide on niobia catalysts for environmental applications, palladium catalysts supported on titania for hydrogen peroxide synthesis, methane combustion catalyst stability, and chiral catalyst deactivation. In summary, this book covers much of the breadth and points to the depth of Professor Bartholomew’s illustrious career. We thank him for his kind example and honor him for his lasting contributions.

Small businesses were at the heart of the economic growth and social transformation that characterized the Industrial Revolution in Britain. In towns across north-west England, shops and workshops dominated the streetscape, and helped to satisfy an increasing desire for consumer goods. Yet, despite their significance, we know surprisingly little about these firms and the people who ran them, for, while those engaged in craft-based manufacturing, retailing, and allied trades constituted a significant proportion of the urban population, they have been generally overlooked by historians. Instead, our view of the world of business is more usually taken up by narratives of particularly successful firms, and especially those involved in new modes of production. By examining some of the forgotten businesses of the Industrial Revolution, and the men and women who worked in them, this book presents a largely unfamiliar commercial world. Its approach, which spans economic, social, and cultural history, as well as encompassing business history and the histories of the emotions, space, and material culture, alongside studies of personal testimony, testatory practice, and property ownership, tests current understandings of gender, work, family, class, and power in the late eighteenth and early nineteenth centuries. It provides us with new insights into the lives of ordinary men and women in trade, whose relatively mundane lives are easily overlooked, but who were central to the story of a pivotal period in British history.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Das »Deutsche Schifffahrtsarchiv« (DSA) ist das seit 1975 erscheinende wissenschaftliche Periodikum des Deutschen Schifffahrtsmuseums/Leibniz-Institut für Maritime Geschichte (DSM). Schwerpunkt ist die deutsche Schifffahrtsgeschichte in ihren globalen Verflechtungen. Die Beiträger*innen in Band 41 zeigen die Vielfalt der schifffahrtsgeschichtlichen Forschung innerhalb verschiedenster Fachdisziplinen.

This open access edited book investigates European social rights in practice from socio-legal perspectives. It brings together fourteen socio-legal scholars, representing Nordic and Western European countries, who analyse different aspects pertaining to European social rights, namely the regulation of social rights, encounters between welfare professionals and citizens, and citizens’ mobilisation of social rights. These three different aspects from the structure for the sections in the anthology, each analysing transformations related to regulation, encounters and rights mobilisation. The book contributes to the existing literature as it focuses on interdependent transformations on macro, meso and micro levels which are key for understanding processes and contexts related to European social rights in practice. It speaks particularly to academics in sociology of law and/or regulation.