Open Access Books

Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease.

This volume showcases how concept-based language instruction (C-BLI) can be effectively integrated into foreign language instruction. C-BLI is grounded in the relationship between theory, research, and practice, incorporating visual aids called SCOBAs (schemas for a complete orientating basis of action) designed to teach accurate scientific concepts. SCOBAs materialize L2 usage-based linguistic and cultural concepts to create tools that promote conceptual understanding and internalization. Three overview chapters lay out the book’s sociocultural theoretic foundations, the role of mediation, usage-based linguistics, and the concept of subjective construal; internalization and its role in re-mediating the mind for L2 learning; and L2 pragmatics teaching and assessment. Subsequent chapters enact praxis via classroom research on C-BLI. Each study focuses on a difficult-to-acquire area of Japanese pragmatics and/or grammar, incorporating SCOBAs that teach core concepts; instruction moves from SCOBA-mediated interactive lecture to internalization tasks involving languaging to language practice. Each chapter concludes with a section for critical reflection to inform future research and materials design. With its focus on research-teaching connections via praxis elucidating the power of linking concept-based language instruction with usage-based linguistics, this book will interest students and scholars of second language acquisition, language teaching and learning, applied linguistics, Japanese, and Asian languages. Chapter 1 of this book is freely available as a downloadable Open Access PDF at " http://www.taylorfrancis.com" "http://www.taylorfrancis.com" under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

It is important to prevent and manage the frailty of the elderly because their muscle strength and physical activity decrease in old age, making them prone to falling, depression, and social isolation. In the end, they need to be admitted to a hospital or a nursing home. When successful aging fails and motor ability declines due to illness, malnutrition, or reduced activity, frailty eventually occurs. Once frailty occurs, people with frailty do not have the power to exercise or the power to move. The functions of the heart and muscles are deteriorated more rapidly when they are not used. Consequently, frailty goes through a vicious cycle. As one’s physical fitness is deteriorated, the person has less power to exercise, poorer cognitive functions, and inferior nutrition intake. Consequently, the whole body of the person deteriorates. Therefore, in addition to observational studies to identify risk factors for preventing aging, various intervention studies have been conducted to develop exercise programs and apply them to communities, hospitals, and nursing homes for helping the elderly maintain healthy lives. Until now, most aging studies have focused on physical frailty. However, social frailty and cognitive frailty affect senile health negatively just as much as physical frailty. Nevertheless, little is known about social frailty and cognitive frailty. This special issue includes original experimental studies, reviews, systematic reviews, and meta-analysis studies on the prevention of senescence (physical senescence, cognitive senescence, social senescence), high-risk group detection, differentiation, and intervention.

This open access book offers a rich and nuanced analysis of digitally networked socialities as culturally meaningful relationships of Touch. Focusing on the ways Touch is practised in everyday social interactions serves as a basis for how Touch is understood as multiply significant – physically, emotionally, intellectually and politically. Andreallo initiates a map of the fundamentals of Touch and how they can be considered for future research in considering digitally networked cultures. This map also serves as a basis for closely examining selfies and memes. Examining social networks of Touch, Andreallo focuses on a specific example of the PrettyGirlsUglyFaces meme and ugly selfies(uglies). Through this example, memes and selfies are mapped as Touch involving textures of both intimacy and violence. Andreallo also discusses technological seamlessness and cultural semefulness as conversations of social relationships of Touch, and proposes the term semeful sociabilities to describe how the everyday technological self engages in practices of Touch. This book is a compact, approachable insight into selfies and memes as everyday culturally networked Touch relationships that also offers a way forward in recognising technological relationships as culturally meaningful.

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Taking a bottom-up perspective, this book explores local framings of a wide range of issues related to benefit-sharing, a growing concept in global environmental governance. Benefit-sharing in Environmental Governance draws on original case studies from South Africa, Namibia, Greece, Argentina, and Malaysia to shed light on what benefit-sharing looks like from the local viewpoint. These local-level case studies move away from the idea of benefit-sharing as defined by a single international organization or treaty. Rather, they reflect different situations where benefit-sharing has been considered, including agriculture, access to land and plants, wildlife management, and extractives industries. Common themes in the experiences of local communities form the basis for an exploration of spaces for local voices at the international level in the Convention on Biological Diversity (CBD), often argued to be the most open arena to non-state actors, and therefore vital to how local voices may be included at the global level. The book analyzes the decisions of the CBD parties to produce an in-depth reflection on how this arena builds and delimits spaces for the expression of local community themes, and paths for local community participation including community protocols. The book then situates the bottom-up findings in the wider debate about global civil society and deliberative democracy in environmental governance. This interdisciplinary book will be of great interest to students and scholars of environmental politics, environmental law, political ecology and global governance, as well as practitioners and policymakers involved in multilateral environmental agreements.

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O professor e arquiteto Mário Mendonça de Oliveira lançou em Salvador, por intermédio da editora da Universidade Federal da Bahia, um tratado inédito de Engenharia Militar, escrito em Pernambuco pelo Brigadeiro Diogo da Silveira Vellozo, e intitulado "Arquitetura Militar ou Fortificação Moderna", um texto interessantíssimo do século XVIII, que consegue desvendar, para os não iniciados, os segredos da fortificação abaluartada e da engenharia da época. Trata-se de texto obrigatório para historiadores, engenheiros, arquitetos e restauradores. O professor Mário Mendonça organizou e transcreveu o manuscrito, acrescentando abundantes notas explicativas que aclaram o texto original, que contém ainda 49 pranchas de desenhos que foram reproduzidos com sistema digital. É um documento que permite ver a grande erudição e conhecimento deste personagem da construção do Brasil. Este livro vem se juntar a outra publicação recente do professor Mário Mendonça, "As Fortificações Portuguesas de Salvador", ambas obras fundamentais para o conhecimento das fortificações militares no Brasil.

This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. There has been an increasing interest in research ethics over the last decade given the increasing ethical regulation of social research. 'Ethical literacy' encourages researchers to understand and engage with the ethical issues that emerge in the process of research. This book provides a short, succinct and accessible overview of the field, highlighting the key issues and everyday ethical dilemmas that researchers are likely to face in different contexts. Covering a range of methods, the book provides clear guidance for researchers on how to identify an approach that fits with their moral and intellectual framework. It explores ethical issues relating to 'traditional' research methods as well as to new and emerging methods and approaches - particularly visual and online methods.

The “West” is a central concept in public discourse, but its meaning is often unclear and open to manifold interpretations and ascriptions of belonging and exclusion: Who is part of the “West”? When and where is it located? Who are the mediators of the “West”? This book aims to stimulate a critical reflection on ideas of the “West” in the history of education by gathering scholars from various fields of historical research.

This open access book provides a detailed example of arts-based knowledge translation from start to finish for any scholar interested in communicating research findings through art. Firmly grounded in the GeoHumanities, a field at the intersection of cultural geography and the arts, this book explores the theory and practice of research exhibitions. Commencing with an overview of arts in health and art-science collaborations, this book also explores the concept of ‘affective knowledge translation’. In doing so, it describes the creative co-production, staging, and evaluation of the Finding Home exhibition which toured Australia during 2021. As a demonstration of the power of art to engage audiences, raise awareness of social issues, communicate lived experience, and extend the reach of cultural geographic research, this book is relevant to academics from any discipline who are keen to increase the societal impact of their work.

The paper draws on Riccardo Del Punta's paper on parental leave, published entry into force of the reform, to examine its subsequent evolution, questioning the relationship between the distribution of care responsibilities and women's labor market participation.

This concise bibliography on South-African Languages and Linguistics was compiled on the occasion of the 20th International Congress of Linguists in Cape Town, South Africa, in July 2018. The selection of titles is drawn from the Linguistic Bibliography and gives an overview of scholarship on South African language studies over the past 10 years.

Despite concerns about declining literacy, Dutch-language children’s and young adult literature enjoys considerable recognition both nationally and internationally. Enthusiasm among researchers to study this field is also growing, from a variety of perspectives and with attention to a wide range of themes. This book showcases that diversity. Rather than confining children’s literature to a single category, the authors deliberately look beyond boundaries. Central to the volume is the interaction between Dutch-language children’s and young adult literature and literatures in other languages, cultures of other countries, adult literature, the visual arts, theatre, and education.

This volume, born from the collaboration of thirty-four scholars and trade union representatives, has a dual purpose. Firstly, to propose the analysis and theses on the human and political meaning of work contained in Bruno Trentin’s main book La città del lavoro (2nd ed., Firenze University Press, 2014), in the current phase of social transformations and theoretical uncertainties. Secondly, to promote a reflection testing the book’s fertility and topicality in order to deepen the processes at work at the start of the 21st century, in the belief that the pages written in 1997 by one of the greatest representatives of the history of the CGIL represent a 'classic' of the socio-political thought of the 20th century. The emerging result is surprising in many ways, and corresponds to the extraordinary richness of Trentin’s project, as well as to the political and trade-unionist ability of its author. TUESDAY, MAY 17 Sede Nazionale della CGIL (Sala Santi) - Corso d'Italia 25 - Rome Presentation of the book “Bruno Trentin e il lavoro dopo il Novecento