Reset
Showing 20 of 23,220 academic articles

Wild immunology

Amy B. Pedersen, Simon A. Babayan • Molecular Ecology (2011)

In wild populations, individuals are regularly exposed to a wide range of pathogens. In this context, organisms must elicit and regulate effective immune responses to protect their health while avoiding immunopathology. However, most of our...

OPENALEX DOI: https://doi.org/10.1111/j.1365-294x.2010.04938.x

Immunology of Psoriasis

Michelle Anne Lowes, Mayte Suárez‐Fariñas, James G. Krueger • Annual Review of Immunology (2014)

The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneo...

OPENALEX Open Access DOI: https://doi.org/10.1146/annurev-immunol-032713-120225 PMC: 4229247

DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa

Uppala Radhakrishna, Uppala Ratnamala, Devendrasinh D. Jhala, Lavanya V. Uppala et al. • Frontiers in Immunology (2024)

BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, bu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2024.1475424

Lung cancer tumor immune microenvironment: analyzing immune escape mechanisms and exploring emerging therapeutic targets

Zhen Wang, Honglei Guo, Yanqi Song, Aidi Wang et al. • Frontiers in Immunology (2025)

Lung cancer is the most common malignant tumor in the world. Presently, there are still problems, including a high recurrence rate, resistance, and serious toxic side effects, even if conventional treatments like chemotherapy, radiotherapy,...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2025.1597686

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v1; ref status: indexed, http://f1000r.es/201]

Benjamin K Dickerman, Jocelyn A McDonald, Ganes C Sen • F1000Research (2013)

The primary function of the dsRNA binding protein (dsRBP) PACT/RAX is to activate the dsRNA dependent protein kinase PKR in response to stress signals.  Additionally, it has been identified as a component of the small RNA processing pathway...

DOAJ Open Access (DOAJ) DOI: 10.12688/f1000research.2-220.v1

Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines

Ella A. Zuiderwijk-Sick, Céline van der Putten, Raissa Timmerman, Jennifer Veth et al. • Frontiers in Immunology (2021)

Interleukin (IL)-4 is a cytokine that affects both adaptive and innate immune responses. In the central nervous system, microglia express IL-4 receptors and it has been described that IL-4-exposed microglia acquire anti-inflammatory propert...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2021.771453