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Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering et al. • Respiratory Research (2025)

Abstract Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, generation, and cultivation time r...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12931-025-03132-w

Clinical characteristics of and risk factors for secondary bloodstream infection after pneumonia among patients infected with methicillin-resistant Staphylococcus aureus

Fangfang Huang, Ting Shen, Xin Hai, Huiqing Xiu et al. • Heliyon (2022)

Purpose: To investigate the clinical features and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia (MP) with secondary MRSA bloodstream infections (MRSA-BSI) (termed MP-BSI) compared with MP alone and to study t...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2022.e11978

Case Report: Tocilizumab in pediatric febrile infection-related epilepsy syndrome

Lingyu Pang, Lingyu Pang, Lingyu Pang, Xuefang Liu et al. • Frontiers in Immunology (2026)

Background and purposeWe describe the clinical characteristics and the therapeutic effect of tocilizumab with Febrile Infection-Related Epilepsy Syndrome (FIRES). FIRES is characterized by super refractory status epilepticus (SRSE) in previ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2026.1767388

The LEGACy study: a European and Latin American consortium to identify risk factors and molecular phenotypes in gastric cancer to improve prevention strategies and personalized clinical decision making globally

Tessa Suzanne van Schooten, Sarah Derks, Elena Jiménez-Martí, Fatima Carneiro et al. • BMC Cancer (2022)

Abstract Background Gastric Cancer (GC) is the fourth most deadly cancer worldwide. Enhanced understanding of its key epidemiological and molecular drivers is urgently needed to lower the incidence and improve outcomes. Furthermore, tumor b...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12885-022-09689-9

Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

Yun Chen, Yun Chen, Kangrong Wang, Kangrong Wang et al. • Frontiers in Pharmacology (2025)

BackgroundHydrogen gas (H2), which is the lightest and diffusible gas molecule, has strong abilities to alleviate excessive oxidative stress, inflammation, and apoptosis. Inhalation of H2 is beneficial for preventing the damage of the lung,...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2025.1575106

Study of serum Total Immunoglobulin E in Egyptian patients with newly diagnosed colorectal carcinoma

Wessam Eid, Fawzia Abo Ali, Sara Taha, Sara Zaki et al. • Zagazig University Medical Journal (2022)

Total immunoglobulin E (IgE) has roles in allergy and anti-parasitic immunity. Recently IgE showed a major role in cancer immune surveillance; an increased risk of solid and blood malignancies has been associated with total IgE deficiency. ...

DOAJ Open Access (DOAJ) DOI: 10.21608/zumj.2022.130517.2541

Period of Arrhythmia Anchored around an Infarction Scar in an Anatomical Model of the Human Ventricles

Daria Mangileva, Pavel Konovalov, Arsenii Dokuchaev, Olga Solovyova et al. • Mathematics (2021)

Rotating nonlinear waves of excitation in the heart cause dangerous cardiac arrhythmias. Frequently, ventricular arrhythmias occur as a result of myocardial infarction and are associated with rotation of the waves around a post-infarction s...

DOAJ Open Access (DOAJ) DOI: 10.3390/math9222911

Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors

Safwaan H. Khan, Safwaan H. Khan, Yeonjoo Choi, Mysore Veena et al. • Frontiers in Immunology (2025)

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, achieving remarkable clinical success with FDA-approved therapies targeting CD19 and BCMA. However, the extension of these successe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2024.1489827

Invertebrate Ecological Immunology

Jens Rolff, Michael T. Siva‐Jothy • Science (2003)

Ecological immunology is a rapidly expanding field that examines the causes and consequences of variation in immune function in the context of evolution and of ecology. Millions of invertebrate species rely solely on innate immunity, compar...

OPENALEX DOI: https://doi.org/10.1126/science.1080623