Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection
Overview & Synopsis
AbstractMicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
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Document Information
| Document Title | Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection |
|---|---|
| Author / Organization | Jing Yang, Xinmei Huang, Yuzhuo Liu, Dongmin Zhao, Kaikai Han, Lijiao Zhang, Yin Li, Qingtao Liu |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2020 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-70121 |
| Original Source Link | Visit Source Page on hal.science » |