Open Access Books

Foreseeing and planning for all of the possibilities and pitfalls involved in bringing a biotechnology innovation from inception to widespread therapeutic use takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures. Unfortunately there has been a dearth of resources for this aspect of the field.

As a prerequisite for further interpretations, the present study will first cover the data of the investigated development in a comprehensive source analysis. These linguistic historical data can then be related to the background of external linguistic history and general typological assumptions about the development of styling systems. In addition, the peculiarities of Czech development should be made clear by comparison with the corresponding developments in Polish and German. On this basis, an overall characteristic of the development of the pronominal salutation in Czech and an assessment of the role of National Rebirth will be attempted.

The essay deals with the relationship between values and labor law following in the first part a logical thread that moves from two essential foundations: Europe and the trade union. The author considers the crisis of these references as a crucial moment in the transformation of the value system. The dialectic between the different perspectives of labor law and the antithesis on the same vision of work in post-modern society are now reflected in the changes in the world of work. The current situation is being crossed by the pandemic crisis, which is also changing the way of understanding work. The prospect of degrowth and the crisis of the capitalist development model impose problems and new values, a renewed relationship between ethics and labor law.

Happiness and Utility brings together experts on utilitarianism to explore the concept of happiness within the utilitarian tradition, situating it in earlier eighteenth-century thinkers and working through some of its developments at the end of the nineteenth and beginning of the twentieth centuries. Drawing on a range of philosophical and historical approaches to the study of the central idea of utilitarianism, the chapters provide a rich set of insights into a founding component of ethics and modern political and economic thought, as well as political and economic practice. In doing so, the chapters examine the multiple dimensions of utilitarianism and the contested interpretations of this standard for judgement in morality and public policy.

Kinetics of Enzymatic Synthesis gives insight into different aspects of chemical reactions that are catalyzed by enzymes. This book is divided into two sections: 'Enzyme Kinetics' and 'Enzymatic Synthesis'. The first section consists of two chapters with a halophilic enzyme kinetics and thermodynamic approach towards analyzing the influence of co-solvents on the Michaelis constants of enzyme-catalyzed reactions. The second section consists of three chapters. Production of isoamyl acetate using the enzymatic synthesis method between acetic anhydride and isoamyl alcohol by having enzyme Candida antarctica Lipase B as catalyst in a solvent-free system is discussed in the third chapter. The integrated scheme with the use of the filtrate from the pretreatment of the CS and the growth conditions of Pleurotus cystidiosus is studied in the fourth chapter. The last chapter of this section provides the conditions of the key parameters in microfluidic systems (residence times, flow rates, concentrations) applied for a sequential process from liquid/liquid extraction of LVV-h7.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has probably been the most important disease to emerge in the 21st century. This viral zoonotic disease has been a significant cause of morbidity and mortality worldwide, but with a higher impact in low- and middle-income countries of Africa, Asia, and Latin America. Up to December 4, 2022, more than 645,195,564 cases had been reported globally, with 6,640,845 deaths, and more than 13,054,668,703 doses of a vaccine had been given. Research has been of the utmost importance in the COVID-19 crisis: a great deal of knowledge was gathered between December 2019 and December 2022. Appropriate evidence-based management and the development of safe and effective vaccines have been key to controlling the virus. This book presents a selection of the last two years’ learning from research and clinical practice concerning SARS-CoV-2/COVID-19.

Bilder sind Teil der medialen Öffentlichkeit, sie konstruieren Gesellschaft. Wie machtvoll sind sie dabei? Die Autorin untersucht die soziale Gestaltung von Pressebildern in Tageszeitungen. In Feininterpretationen werden die gestalterischen Routinen der Redaktionen nachgezeichnet. Zudem wird gezeigt, wie bei der Veröffentlichung um die Auslegung der Bilder gerungen wird. Die Autorin entwickelt die qualitative Bildanalyse innovativ weiter und liefert zugleich einen eigenständigen Beitrag zur Diskussion um die Macht der Bilder.

Systems biology is the inevitable outcome of long years of knowledge acquisition and data accumulation. The aim of systems biology is to integrate in a seamless way all existing knowledge in interconnected disciplines, stretching from modern biomedical research to physics, chemistry, and mathematics. The main integration tool of such complex biomedical systems is via computational and mathematical modeling. In this direction, a series of state-of-the-art computer science techniques are used, namely, data mining and fusion, machine learning, and deep learning all under the prism of big data. All in all, systems biology is at the arrowhead of modern and state-of-the-art biomedical research by attempting to address key biological questions describing holistically complex biological systems.

Sex and gender in biomedicine are innovative research concepts of theoretical and clinical medicine that enable a better understanding of health and disease, evidence-based knowledge, effective therapies, and better health outcomes for women and men. Gender Medicine stimulates new ways of doing research: that is to consider sex and gender at all levels of research, from basic research into gene polymorphisms to health behaviour. New research questions have been put forward that focus not on differences per se but on the development of differences. In this book, contributions from the field of neuroscience, addiction research, and organ transplantation exemplify concepts, approaches, methods and results in the field.

All organizations, institutions, business processes, markets and strategies have one aim in common: the reduction of transaction costs. This aim is pursued relentlessly in practice, and has been perceived to bring about drastic changes, especially in the recent global market and the cyber economy. This book analyzes and describes “transactions” as a model, on the basis of which organizations, institutions and business processes can be appropriately shaped. It tracks transaction costs to enable a scientific approach instead of a widely used “state-of-the-art” approach, working to bridge the gap between theory and practice. This open access book analyzes and describes “transactions” as a model...

"The role of parents in shaping the characters of their children, the causes of violence and crime, and the roots of personal unhappiness are central to humanity. Like so many fundamental questions about human existence, these issues all relate to behavioural development. In this lucid and accessible book, eminent biologist Professor Sir Patrick Bateson suggests that the nature/nurture dichotomy we often use to think about questions of development in both humans and animals is misleading. Instead, he argues that we should pay attention to whole systems, rather than to simple causes, when trying to understand the complexity of development. In his wide-ranging approach Bateson discusses why so much behaviour appears to be well- designed. He explores issues such as ‘imprinting’ and its importance to the attachment of offspring to their parents; the mutual benefits that characterise communication between parent and offspring; the importance of play in learning how to choose and control the optimal conditions in which to thrive; and the vital function of adaptability in the interplay between development and evolution. Bateson disputes the idea that a simple link can be found between genetics and behaviour. What an individual human or animal does in its life depends on the reciprocal character of its transactions with the world about it. This knowledge also points to ways in which an animal's own behaviour can provide the variation that influences the subsequent course of evolution. This has relevance not only for our scientific approaches to the systems of development and evolution, but also on how humans change institutional rules that have become dysfunctional, or design public health measures when mismatches occur between themselves and their environments. It affects how we think about ourselves and our own capacity for change."

After the First World War, Britain faced a number of challenges as it sought to adapt to domestic conditions of mass democracy while maintaining its position in the empire in the face of national independence movements. As politicians at home and abroad sought to legitimize their position, new efforts were made to conceptualize nationality and citizenship, with attempts to engage the public using mass media and greater emphasis on governing in the public interest. Brave New World reappraises the domestic and imperial history of Britain in the inter-war period, investigating how 'nation building' was given renewed impetus by the upheavals of the First World War. The essays in this collection address how new technologies and approaches to governance were used to forge new national identities both at home and in the empire, covering a wide range of issues from the representation of empire on film to the convergence of politics and 'star culture'. The book is an invaluable resource for scholars of British social, political and imperial history, as well as being of interest to the general reader.

In today’s ‘publish or perish’ academic setting, the institutional prizing of quantity over quality has given rise to and perpetuated the dilemma of predatory publishing. Upon a close examination, however, the definition of ‘predatory’ itself becomes slippery, evading neat boxes or lists which might seek to easily define and guard against it. This volume serves to foreground a nuanced representation of this multifaceted issue. In such a rapidly evolving landscape, this book becomes a field guide to its historical, political, and economic aspects, presenting thoughtful interviews, legal analysis and original research. Case studies from both European-American and non-European-American stakeholders emphasize the worldwide nature of the challenge faced by researchers of all levels. This coauthored book is structured into both textual and supplemental materials. Key takeaways, discussion questions, and complete classroom activities accompanying each chapter provide opportunities for engagement and real-world applications of these concepts. Crucially relevant to early career researchers and the senior faculty, library scholars, and administrators who mentor and support them, 'The Predatory Paradox: Ethics, Politics, and Practices in Contemporary Scholarly Publishing' offers practical recommendations for navigating the complex and often contradictory advice currently available. University instructors and teaching faculty will also find the reading essential in order to properly prepare both graduate and undergraduate students for the potential pitfalls endemic to scholarly publishing.

"Blackbox", "Opazität" oder "Intransparenz" - der Technologie des maschinellen Lernens ist Nichtwissen inhärent. Aus dieser soziologisch geprägten analytischen Perspektive bringt Iva Kostov verschiedene soziale Praktiken und technologische Eigenschaften bei maschinellem Lernen auf einen gemeinsamen Nenner und untersucht ihre Bedeutung für das Recht. Dies erfolgt unter Bezugnahme auf einen für die Analyse der Thematik besonders anschlussfähigen Bereich sicherheitsbehördlicher Tätigkeit. Unter Systematisierung der verschiedenen interdisziplinären Diskussionen entwickelt sie eine für das Recht produktive Typologie verschiedener Nichtwissensausprägungen, arbeitet die jeweils maßgeblichen rechtlichen Fragestellungen heraus und zeigt Mechanismen zum Umgang damit auf. Zugleich entlarvt sie einige vieldiskutierte Themen als rechtlich irrelevante Scheinprobleme.

In 1907, Korean independence activist and nationalist historian Chae-Ho Shin translated the Chinese edition of The Makers of Modern Italy into a Korean–Chinese script and published it under the title Three Great Founders of Italy. This article aims to investigate Chae-Ho Shin’s intentions and purposes, as shown in his Three Great Founders of Italy, to reveal how he re-contextualised the history of the Italian Risorgimento. Chae-Ho Shin’s re-contextualisation was inextricably bound up with the historical setting of the political crisis that Korea faced after the Japan-Korea Treaty of 1905.