Academic Articles & Research Papers

Two Novel ATP2C1 Mutations in Portuguese Patients with Hailey-Hailey Disease

Hailey-Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis. It is characterized by a recurrent eruption of vesicles, erosions, and scaly erythematous plaques involving intertriginous areas and first occurring after pub...

First-Trimester Hematologic Inflammatory Markers and Pregnancy Loss in Women With Unexplained Recurrent Pregnancy Loss: A Retrospective Study of Associations and Discrimination.

Dizziness, Scanning Speech, and Transient Hyperreflexia as Atypical Initial Manifestations of Antiganglioside Q1b-Negative Miller Fisher Syndrome: A Case Report and Literature Review.

ScRNA-Seq Reveals Jiangfu Zhixie Formula Alleviates IBS-D by Inhibiting Macrophage M1 Polarization through HIF-1α-Glycolysis Axis.

Ethnic Differences in Clinical Manifestations of Behçet's Disease: A Retrospective Cohort Study of Turkic and Non-Turkic Patients.

Human Pegivirus Type 1 Coinfections: Epidemiology, Heterogeneity and Clinical Implications.

C3a Enhances the Formation of Intestinal Organoids through C3aR1

C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied....

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Abstract Background Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. We aim to co...

Case report: Rapid development of amyloid A amyloidosis in temporal arteritis with SAA1.3 allele; An unusual case of intestinal amyloidosis secondary to temporal arteritis

Temporal arteritis (TA) is a large-vessel vasculitis mostly seen in older patients. Amyloid A (AA) amyloidosis secondary to a chronic inflammation induces multiple organ dysfunctions, including a dysfunction of the gastrointestinal tract. H...

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions

Summary: Detecting antibodies, particularly those targeting donor human leukocyte antigens in organ transplantation and self-antigens in autoimmune diseases, is crucial for diagnosis and therapy. Radioprotective 105 (RP105), a Toll-like rec...

Applications and insights from continuous dengue virus infection in a stable cell line

Dengue is caused by the four serotypes of dengue virus (DENV-1-4) and poses a significant global public health challenge, with an estimated 100–400 million infections annually. Severe dengue manifestations, such as Dengue Hemorrhagic Fever ...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...

Current Trends in Tolerance Induction in Cow's Milk Allergy: From Passive to Proactive Strategies

This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to supp...

Under Pressure: Interactions between Commensal Microbiota and the Teleost Immune System

Commensal microorganisms inhabit every mucosal surface of teleost fish. At these surfaces, microorganisms directly and indirectly shape the teleost immune system. This review provides a comprehensive overview of how the microbiota and micro...

Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect

Purpose: Ultra High Dose-Rate (UHDR) radiation has been reported to spare normal tissue, compared with Conventional Dose-Rate (CDR) radiation. However, important work remains to be done to improve the reproducibility of the FLASH effect. A ...

A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

Abstract Background Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogen...

Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis

Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to d...

Genetic Markers of Adaptation of <named-content content-type="genus-species">Plasmodium falciparum</named-content> to Transmission by American Vectors Identified in the Genomes of Parasites from Haiti and South America

ABSTRACT The malaria parasite, Plasmodium falciparum, was introduced into Hispaniola and other regions of the Americas through the slave trade spanning the 16th through the 19th centuries. During this period, more than 12 million Africans w...

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and...

Efficacy and safety of biofilm dispersal by glycoside hydrolases in wounds

Novel anti-biofilm and dispersal agents are currently being investigated in an attempt to combat biofilm-associated wound infections. Glycoside hydrolases (GHs) are enzymes that hydrolyze the glycosidic bonds between sugars, such as those f...