Academic Articles & Research Papers

Emodin inhibits Newcastle disease virus replication via regulating the phosphorylation levels of eEF2K/eEF2 and targeting viral N protein to reduce viral protein production

Newcastle disease (ND) caused by Newcastle disease virus (NDV) infection is a highly contagious avian disease that causes substantial threat to the global poultry industry. Emodin (EMO), a member of the free anthraquinone compounds derived ...

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.

The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in industrialized settings; nevertheless, APOE ε4-which is ance...

Genetic diversity in pointed gourd (Trichosanthes dioica) genotypes for fruit yield and quality traits under eastern plateau and hill region

The experiment was conducted during summer seasons of 2021–22 and 2022–2023 at ICAR-Research Complex for Eastern Region, Farming System Research Centre for Hill and Plateau Region, Plandu, Ranchi, Jharkhand focused on assessing the genetic ...

De novo SCN1A missense variant in a patient with Parkinson’s disease

BackgroundVariants in a gene encoding sodium voltage-gated channel alpha subunit 1 (SCN1A) are known to cause a broad clinical spectrum of epilepsy and associated features, including Dravet syndrome (MIM 607208), non-Dravet developmental an...

Near infrared spectroscopy predicts crude protein concentration in hemp grain

Abstract This study evaluated near‐infrared spectroscopy (NIRS) for nondestructive crude protein (CP) prediction in hemp (Cannabis sativa L.) grain and validated the biological basis of spectral predictions. Note that 149 whole grain sample...

miRNA-mediated loss of m6A increases nascent translation in glioblastoma.

Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally give rise to GSCs to maintain the cellular equilibrium necessary for optimal tum...

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible <it>IRF1 </it>gene

Abstract Background The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by s...

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or be...

SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross c...

ESTIMATING THE GENETIC PARAMETERS OF YIELD AND YIELD COMPONENT TRAITS IN SQUASH (Cucurbita pepo, L.)

The main objective of this investigation was to determine the genetic parameters, heritability in both broad and narrow senses, combining abilities and correlation foryield and yield component traitsin squash (Cucurbita pepo, L.). For this ...

Genetic impact of non-consanguineous marriages in Saudi Arabia.

Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients and clinicians. The aim of this study was to estimate the hit rate of the non-consanguineous population. Mor...

Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor

Cracking rare disorders: a new minimally invasive RNA-seq protocol

Abstract RNA sequencing (RNA-seq) has become key to complementing exome and genome sequencing for variant interpretation. We present a minimally invasive RNA-seq protocol using short-term cultured peripheral blood mononuclear cells (PBMCs) ...

BRI1 EMS SUPPRESSOR1 genes regulate abiotic stress and anther development in wheat (Triticum aestivum L.)

BRI1 EMS SUPPRESSOR1 (BES1) family members are crucial downstream regulators that positively mediate brassinosteroid signaling, playing vital roles in the regulation of plant stress responses and anther development in Arabidopsis. Important...

Fungal Communities Associated with Siricid Wood Wasps: Focus on <i>Sirex juvencus</i>, <i>Urocerus gigas</i>, and <i>Tremex fuscicornis</i>

We investigated the diversity and occurrence of wood wasps in Lithuania and determined communities of associated fungi. Trapping of wood wasps resulted in three different species, including Sirex juvencus, Urocerus gigas, and Tremex fuscico...

Evaluation of Occupational Accidents in the Forestry Sector Using Standardized Accident Rates: The Case of Türkiye

This study examines work accidents that occurred in the “Forestry and Industrial and Fuel Wood Production” sector in Türkiye between 2007 and 2024. In the research, the number of insured persons, the number of workplaces, and work accident ...

Chromosome-level genome assembly and population genomics analysis of Camellia rubituberculata provide insights into adaptation to karst habitats

Karst flora confined to isolated ‘habitat islands’ evolve specialized adaptations and unique traits, serving as ideal models for investigating adaptive evolution and species diversification mechanisms. Camellia rubituberculata, endemic to t...

Assessing the natural durability of different tropical timbers in soil-bed tests

Ground contact speeds up timber decay because of the large number of microorganisms in soil. This study, we assessed the natural durability of seven tropical species using the European standard EN 807 (2001). We embedded samples of Dalbergi...

Anaokulu Bahçelerinde Dış Mekân Optimum Kullanım Olanaklarının Belirlenmesi: İstanbul Anadolu Yakasından Örnekler

Günümüz kentlerinde çocukların en çok vakit geçirdiği yerin okul binası ve okul bahçesi olduğu düşünüldüğünde anaokulu bahçeleri ve bahçede oynanan oyunlar çocukların fiziksel, ruhsal ve zihinsel gelişimlerinin sağlıklı ilerleyişi açısından...

Les hêtres (Fagus sylvatica L.) de la forêt de Valbonne (Gard), sujets d’une polémique close et exception génétique

La forêt domaniale de Valbonne (Gard) est située à l’étage supraméditerranéen. La présence de petits lambeaux de hêtraie a étonné les forestiers dès 1920. Essence relictuelle ou plantation des Chartreux, anciens propriétaires ? Dans les ann...