Copper Catalyzed Decarboxylative Functionalization of Ketoacids

Overview & Synopsis

Selective copper catalyzed activation of ketoacids and notably bio-sourced 1,3acetonedicarboxylic acid, represents an attractive strategy to solve key synthetic challenges. Condensation with aldehydes under exceedingly mild conditions can create more rapidly known natural products scaffolds such as 1,3 polyols. In this account, the recent progress in this field, notably through multicatalytic combination with organocatalysis is described. In addition to the rapid preparation of natural product fragments, cascade incorporation of fluorine also provided new type of synthetic analogues of improved properties in a broad range of applications.