BIOMIMETIC IONIC MICROSTIMULATION FOR NEURON CULTURE
Overview & Synopsis
Here, we propose a novel microfluidic system to investigate the response of the neurons directly stimulated by the potassium ions in vitro. Unlike the conventional way of stimulating neurons by pipetting or sending electrical stimulus, this biomimetic stimulation system enables precise and rapid control of ion concentration by utilizing microfluidic pneumatic valves, which mimics physiological stimulation in a body. By using the system, we demonstrated stimulations of the neuron cells with potassium ions and monitored neural activities with a calcium-specific fluorescence indicator.
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hal.science)
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Document Information
| Document Title | BIOMIMETIC IONIC MICROSTIMULATION FOR NEURON CULTURE |
|---|---|
| Author / Organization | Stephany Mai Nishikawa, Soo Hyeon Kim, Yoshiho Ikeuchi, Teruo Fujii, Timothée Levi |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2018 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-7673 |
| Original Source Link | Visit Source Page on hal.science » |