Cocaine withdrawal enhances subthalamic reward sensitivity
Overview & Synopsis
High-frequency stimulation of the subthalamic nucleus (STN) has shown therapeutic potential in preclinical models of addiction. However, its rewarding properties remain unclear. Here, we show that cocaine withdrawal enhances STN intracranial self-stimulation, revealing a reward-based mechanism that may contribute to the beneficial effects of STN deep brain stimulation in addiction and related neuropsychiatric disorders.
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hal.science)
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Document Information
| Document Title | Cocaine withdrawal enhances subthalamic reward sensitivity |
|---|---|
| Author / Organization | Maya Williams, Cassandre Vielle, Jeanne-Laure de Peretti, Alix Tiran-Cappello, Christophe Melon, Ali Awada, Yann Pelloux, Nicolas Maurice, Christelle Baunez, Mickael Degoulet |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2025 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-74763 |
| Original Source Link | Visit Source Page on hal.science » |