NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, "Cold" Analogs of PET/SPECT Tracers
Overview & Synopsis
Ga-complexes are widely used as radiopharmaceuticals for PET or SPECT imaging and as therapeutic agents. At physiological pH, free gallium(III) ions can stably exist as soluble gallate [Ga(OH)4]−, a nephrotoxic compound whose presence should be avoided. Any Ga-complex, therefore, should be carefully checked for the absence of gallate before use. Here we show that 71Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga-complexes and to follow the purification steps of the Ga-complex solutions.
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Document Information
| Document Title | NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, "Cold" Analogs of PET/SPECT Tracers |
|---|---|
| Author / Organization | Qiuju Zhou, Céline Henoumont, Luce Vander Elst, Sophie Laurent, Robert N Muller |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2011 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-33212 |
| Original Source Link | Visit Source Page on hal.science » |