Observability-Aligned Diffusion and Null-Space Completion for EEG Source Localization

Overview & Synopsis

Electrophysiological source imaging is severely underdetermined because the lead-field matrix has limited rank relative to the source dimension and strongly correlated columns. Scalp EEG measurements constrain only the observable row-space component, leaving a high-dimensional null space unobservable. We propose a two-stage framework coupling posterior diffusion refinement with deterministic null-space completion. A minimum-norm-initialized, singular-coordinate Posterior-DDIM sampler combines a spatiotemporal diffusion prior with direction-dependent measurement reliability to refine the observable component. A frozen ridge predictor and nonlinear temporal residual network then estimate the null component under explicit projection constraints, preserving the refined row estimate and its predicted EEG exactly. All learned components are trained exclusively on simulated cortical activity and its row-null decomposition, without paired EEG-source training data. Across simulations with varying noise levels, the method achieved higher frame-level area under the receiver operating characteristic curve and average precision, together with lower localization error, than conventional and learning-based baselines. Exploratory evaluations on evoked EEG and simultaneous scalp EEG-stereo-EEG recordings showed condition- and event-dependent concordance with cross-modal and intracranial references.