N-(2-pyridyl)sulfonyl groups for ortho-directing palladium carbon-halogen bond formation at functionalized arenes
Overview & Synopsis
We describe an efficient palladium‐catalyzed selective C–H ortho ‐monohalogenation (X=I, Br, Cl, F) of various functionalized (2‐pyridyl)arylsulfones. ortho‐ , meta‐ and para ‐functionalization is tolerated at the arene group which undergoes C–H halogenation. Some modifications are also possible on the 2‐(arylsulfonyl)heteroaryl directing groups. A comparison of the halogenation efficiency suggests that bromination is the practical method of choice, while chlorination and fluorination are possible but more challenging. Under forcing conditions ortho ‐dihalogenation can also be achieved. magnified image
Indexed from repository: HAL Open Science
(
hal.science)
Keyboard Shortcuts:
← / → for pages • + / - for zoom • 0 to fit width
Powered by Mozilla PDF.js v3.11
Document Information
| Document Title | N-(2-pyridyl)sulfonyl groups for ortho-directing palladium carbon-halogen bond formation at functionalized arenes |
|---|---|
| Author / Organization | Johan Guilbaud, Marine Labonde, Hélène Cattey, Sylvie Contal, Christian Montalbetti, Nadine Pirio, Julien Roger, Jean-Cyrille Hierso |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2017 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-22766 |
| Original Source Link | Visit Source Page on hal.science » |