The interaction between nonalcoholic steatosis, anthropometric indicators and disturbance of lipid peroxidation and antioxidant defense in patients with signs of obesity

Overview & Synopsis

Aim - to study charac­teristics of indicators of lipid peroxidation (LPO) and antioxidant system (AOS), depending on the body mass index (BMI) in patients with non-alcoholic steatosis (NASP) in combination with obesity (OB) and pathology of the biliary tract (BT). The study involved 100 patients with NASP in combination with OB and BT pathology, who at the time of sonographic and morphological study of liver biopsy presented signs of hepatic steatosis. Among the patients there were 19 men and 81 women. The average age of patients - (53,67 ± 1,11) years. The control group consisted of 20 practically healthy persons (PHP). BMI is determined by the formula Quetelet. Depending on the degree of BMI increase all patients with NASH and obe­sity were divided into three groups: 1 group – with BМI 25-29,9 kg/m2– ex­cessive body mass; 2 group – with BMI 30-34,9 kg/m2– obesity of I degree; 3 group – with BMI 35–39,9 kg/m2– obesity of ІІ degree. Status of LPO system was assessed by the concentration of malondialdehyde in plasma and red blood cells and the content of lipid peroxidation intermediates in the two phases of the lipid extract – isolated double bonds, diene conjugates, oksidien conjugates and the final LPO products – schiff bases. Factors of antioxidant defense activity were assessed by ceruloplasmin (CP), superoxide dismutase (SOD) and catalase in erythrocyte hemolysate. All LPO indicators have been activated in the two phases of lipid extract (from p