Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study
Overview & Synopsis
Aptamers have emerged as promising biorecognition elements for the development of biosensors. The present work focused on the direct detection, by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D), of a low molecular weight (LMW) compound (less than 200 Da) with an aptamer receptor presented as an oriented monolayer on surface. These techniques are powerful for label-free, real-time characterization and quantification of molecular interactions at interfaces. Herein, we analyzed the influence of aptamer surface density on the recognition properties. A decrease of the surface
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hal.science)
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Document Information
| Document Title | Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study |
|---|---|
| Author / Organization | Hannah Macdonald, Hugues Bonnet, Angéline van Der Heyden, Eric Defrancq, Nicolas Spinelli, Liliane Coche-Guerente, Jérôme Dejeu |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2019 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-215329 |
| Original Source Link | Visit Source Page on hal.science » |