Tipping the balance in histone supply puts genome stability at stake
Overview & Synopsis
Specific localization of the histone H3 variant CENP-A at centromeres is key for faithful chromosome segregation during cell division, with CENP-A mislocalization being associated with chromosomal instability and cancer. New work in The EMBO Journal identifies the H3-H4 chaperone DNAJC9 as a factor restricting CENP-A localization, underscoring the importance of balancing H3 and CENP-A histone levels for ensuring proper CENP-A localization and maintaining genome stability.
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hal.science)
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Document Information
| Document Title | Tipping the balance in histone supply puts genome stability at stake |
|---|---|
| Author / Organization | Charlène Renaud-Pageot, Geneviève Almouzni |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2024 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-184365 |
| Original Source Link | Visit Source Page on hal.science » |