Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms
Overview & Synopsis
We established a conditional site–specific recombination system based on dimerizable Cre– mediated recombination in the apicomplexan parasite Toxoplasma gondii. Using a novel single vector strategy that allows ligand-dependent, efficient removal of a gene of interest, we generated three knockouts of apicomplexan genes considered essential for host-cell invasion. Our findings uncover the existence of an alternative invasion pathway in apicomplexan parasites.
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hal.science)
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Document Information
| Document Title | Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms |
|---|---|
| Author / Organization | Nicole Andenmatten, Saskia Egarter, Allison J Jackson, Nicolas Jullien, Jean-Paul Herman, Markus Meissner |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2013 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-16454 |
| Original Source Link | Visit Source Page on hal.science » |