Cross-reactivity of some commercially available DON and ZEN immunoaffinity columns to DON and ZEN conjugated forms and metabolites
Overview & Synopsis
Abstract Seven commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns (IACs) were tested for cross-reactivity to conjugated forms (3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, DON-3-glucoside, DON-3-glucuronide, ZEN-glucosides, ZEN-glucuronide) and metabolites (de-epoxydeoxynivalenol, α-zearalenol, β-zearalenol) and nivalenol (NIV), using a semi-quantitative multi-mycotoxin ultra performance liquid chromatography - tandem mass spectrometry method. The DON IACs showed cross-reactivity for nearly all DON derivatives tested. The ZEN IACs showed limited cross-reactivity to some of the ZEN derivatives. The IACs were evaluated for their potential use as sample clean-up for mycotoxins in serum.
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Document Information
| Document Title | Cross-reactivity of some commercially available DON and ZEN immunoaffinity columns to DON and ZEN conjugated forms and metabolites |
|---|---|
| Author / Organization | Aleksandrs Versilovskis, Bart Huybrecht, Emmanuel K Tangni, Pussemier Luc, Sarah de Saeger, Alfons Callebaut |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2011 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-159849 |
| Original Source Link | Visit Source Page on hal.science » |