Effects of bradykinin on venous capacitance in health and treated chronic heart failure.
Overview & Synopsis
We investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow in health (G1, n=20) and in chronic heart failure patients treated with angiotensin converting enzyme (ACE) inhibitors (G2, n=16) and angiotensin receptor blockers (ARB) (G3, n=14). We used radionuclide plethysmography to examine the effects of bradykinin and of the bradykinin antagonists B9340 (B1/B2 antagonist) and HOE140 (B2 antagonist). Bradykinin infusion increased unstressed forearm vascular volume in a similar dose dependent manner in G1 and G3 (G1 maximum 12.3±2.1%; p
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Document Information
| Document Title | Effects of bradykinin on venous capacitance in health and treated chronic heart failure. |
|---|---|
| Author / Organization | Prasad Gunaruwan, Abdul Maher, Lynne Williams, James Sharman, Matthias Schmitt, Ross Campbell, Michael Frenneaux |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2009 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-110952 |
| Original Source Link | Visit Source Page on hal.science » |