Minimising conformational bias in fluoroprolines through vicinal difluorination
Overview & Synopsis
Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.
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hal.science)
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Document Information
| Document Title | Minimising conformational bias in fluoroprolines through vicinal difluorination |
|---|---|
| Author / Organization | Gert-Jan Hofman, Emile Ottoy, Mark Light, Bruno Kieffer, Ilya Kuprov, José Martins, Davy Sinnaeve, Bruno Linclau |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2018 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-108972 |
| Original Source Link | Visit Source Page on hal.science » |