Open Access Books

This Reprint comprises eight published papers, covering aspects of the molecular pathology of, and therapeutic approaches to melanoma. Topics covered in the Reprint include therapeutic approaches to treat melanoma, mechanisms of therapeutic resistance and approaches to address therapeutic resistance in melanoma, immune-related pathways and microenvironmental factors that impact melanoma pathobiology, and genomic as well as epigenomic mechanisms involved in melanoma pathobiology or treatment response.

Die Rede vom Logistischen hat einen festen Platz in den Diskursen der Gegenwart. In der kritischen Geografie, den Medienwissenschaften oder den Black Studies verweist sie auf eine machtvolle Operationsweise, die Ströme von Waren, Körpern und Daten organisiert. Wie lässt sich ein solcher Begriff im Kontext von Museen produktiv machen? Dieser Frage geht Melcher Ruhkopf in Hamburg, Antwerpen und der chilenischen Atacama-Wüste nach. Er fokussiert auf Museen, die an zentraler Stelle mit logistischen Fragen befasst sind: Hafenmuseen und maritime Museen. Dabei zeigt sich, wie ein logistischer Blick nicht nur neue Perspektiven auf maritime Objekte eröffnet, sondern auch deren genuin verbindendes und emanzipatorisches Potential aktiviert.

This is an edited collection of nuggets of game design wisdom. It covers various areas in game design with examples from commercially released videogames. Its goal is to share and raise awareness of excellent game design. The contributing authors are B. Barker, M. Caldwell, J. Grahmann, K. Kotter, L. Neuschwander, T. S. Richard, and J. Zagal.

Taking advantage of high resolution, rapid response, and compact structure, piezoelectric actuators are widely employed for achieving precision positioning in both scientific research and industrial application. With the development of science and technology, the requirements for precision positioning are increasing. Accordingly, great efforts have been made to improve the performances of piezoelectric actuators, and significant progress has been achieved. This book discusses some recent achievements and developments of piezoelectric actuators, in terms of piezoelectric material, driving principle, structural design, modeling, and control, as well as applications.

"Human Worth – A Challenge for School and Society addresses the question of whether all human beings’ lives have equal value. To answer, the authors examine how we should understand the value of human life. Human worth and equality are both fundamental principles in education, but there are countless examples of how difficult these concepts can be in actual practice. There is also scant discussion within the school system that touches on our understanding of what human worth in school is. Insofar as school is society’s most important vehicle for human learning and development, we view understanding human worth as a challenge our entire society faces. This book is an anthology in nine chapters about human worth in such typically ‘humanity-oriented’ school subjects as pedagogics, philosophy, social studies, religion, Norwegian, and arts and crafts. The book provides and introduction to defining human worth from a variety of theoretical perspectives, with examples from school and everyday life. The individual chapters pose questions about dignity, equality, inclusion and exclusion, and the resources human beings engage in meeting challenges. "

All the Feels / Tous les sens presents research into emotion and cognition in Canadian, Indigenous, and Québécois writings in English or French. Affect is both internal and external, private and public; with its fluid boundaries, it represents a productive dimension for literary analysis. The emerging field of affect studies makes vital claims about ethical impulses, social justice, and critical resistance, and thus much is at stake when we adopt affective reading practices. The contributors ask what we can learn from reading contemporary literatures through this lens. Unique and timely, readable and teachable, this collection is a welcome resource for scholars of literature, feminism, philosophy, and transnational studies as well as anyone who yearns to imagine the world differently. Contributors: Nicole Brossard, Marie Carrière, Matthew Cormier, Kit Dobson, Nicoletta Dolce, Louise Dupré, Margery Fee, Ana María Fraile-Marcos, Smaro Kamboureli, Aaron Kreuter, Daniel Laforest, Carmen Mata Barreiro, Ursula Mathis-Moser, Heather Milne, Eric Schmaltz, Maïté Snauwaert, Jeanette den Toonder

Chapter 7 of Dynamic Epigraphy: New Approaches to Inscriptions This volume, with origins in a panel at the 2018 Celtic Conference in Classics, presents creative new approaches to epigraphic material, in an attempt to 'shake up' how we deal with inscriptions. Broad themes include the embodied experience of epigraphy, the unique capacities of epigraphic language as a genre, the visuality of inscriptions and the interplay of inscriptions with literary texts. Although each chapter focuses on specific objects and epigraphic landscapes, ranging from Republican Rome to early modern Scotland, the emphasis here is on using these case studies not as an end in themselves, but as a means of exploring broader methodological and theoretical issues to do with how we use inscriptions as evidence, both for the Greco-Roman world and for other time periods. Drawing on conversations from fields such as archaeology and anthropology, philology, art history, linguistics and history, contributors also seek to push the boundaries of epigraphy as a discipline and to demonstrate the analytical fruits of interdisciplinary approaches to inscribed material. Methodologies such as phenomenology, translingualism, intertextuality and critical fabulation are deployed to offer new perspectives on the social functions of inscriptions as texts and objects and to open up new horizons for the use of inscriptions as evidence for past societies.

La réflexion sur l'épistémologie de l'histoire et la théorie littéraire ne sont vraiment légitimes que si l'on prend en compte les textes des historiens anciens dans leur diversité. C'est pourquoi nous proposons d'abord au lecteur de parcourir ce que les Anciens nous disent à propos du genre historiographique et d'examiner sous quelles conditions la théorie littéraire et de l'herméneutique peuvent nous aider. De la promesse (discours programmatique ou polémique) au travail d'écriture, ce recueil, qui résulte d'enseignements consacrés à l'historiographie ancienne, est aussi un livre. Il fallait affronter le risque de la dispersion en commentant des textes très divers et superposer tous ces feuillets en multipliant les références croisées. Un événement (les Ides de Mars), un empire que découvre un Grec (Xénophon et la Perse), une figure éminente (Hannibal) nous ont servi de points d'appui pour dégager les constantes et les variations du discours historiographique des Anciens. Les étudiants de Nanterre et de Nantes, qui nous ont incité à plus de rigueur et nous ont fait lire leurs travaux, méritent ici l'expression de notre gratitude.

Im Zuge dieser Arbeit wird neben der Bestimmung der Grenzflächenhaftung zwischen den Komponenten die unterschiedlichen Verformungs- und Schädigungsmechanismen auf Probenebene unter quasi-statischer Zug- und Druckbelastung, zyklischer Ermüdungsbeanspruchung sowie ebenfalls das zyklische Rissausbreitungsverhalten auf Profilebene beschrieben und geklärt. Daraus abgeleitete Modelle sowie die Verwendung und Modifikation bereits vorhandener Modelle erlauben eine Abschätzung des Verbundverhaltens.

The Inspector General of the Air Force (SAF/IG) is leading an Air Force–wide effort to reduce the burden of Air Force inspection activities while also improving the quality of oversight the inspection system provides. In 2010, SAF/IG asked RAND Project AIR FORCE to join in this effort. This report presents primary data RAND collected on the Air Force inspection system and identifies effective inspection and information collection practices that the Air Force might emulate.

Nothing exceptional happened in front of the youth association building in Kalajoki on 9 September 1953. There was a minor confrontation between regional police forces and local youth, but hundreds of similar events happened in small municipalities across Finland. The event took about ten minutes, nobody was seriously hurt, and collective feelings quickly calmed down. However, after extensive investigations, the regional prosecutor thought otherwise and prosecuted half a dozen local men for rebellion against the state in January 1954. The district court agreed. The municipality was shocked, and the Finnish society was taken by surprise. The case ended up in Supreme Court. This book analyses why and how the last rebellion in the history of Finland occurred in a tiny municipality on the west coast of Finland. The analysis is based on historical microsociology that integrates the insights of microhistory and microsociology into event structure analysis and collective memory studies.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Entre 1914 et 1918, la littérature populaire et de jeunesse met régulièrement en scène des enfants et des adolescents qui aspirent à se battre contre l’ennemi allemand. Leur engagement est pourtant illicite : l’âge minimum requis pour rejoindre l’armée est de 17 ans. Victime, fugueur, vengeur, frondeur, le personnage du combattant juvénile est d’autant plus apprécié du public que les romanciers savent tirer parti du patriotisme propre à la période. Mais ces auteurs cherchent également à peser sur l’opinion des lecteurs, sur leurs convictions. Entre littérature et propagande, ils rusent alors avec les contraintes réglementaires pour justifier les actions de leurs jeunes héros. Exhumant un corpus de romans, nouvelles, contes journalistiques ou historiettes, dont une grande partie, publiée dans des périodiques, était tombée dans l’oubli, Daniel Aranda propose dans cet ouvrage une analyse de ce personnage politiquement incorrect qu’est l’enfant-soldat. Véritable métaphore de la France en danger de mort des premiers mois du conflit, ce dernier sera concurrencé puis supplanté par la figure du « poilu », représentatif de la guerre de position des années suivantes. Une anthologie vient compléter cette étude, offrant à la lecture une trentaine de ces textes jusqu’alors introuvables.

The book takes a multi-disciplinary approach to explore the role national security intelligence agencies played in supporting national governments’ response to COVID-19. Spanning the ‘Five Eyes’ intelligence countries (UK, USA, Canada, Australia and New Zealand), this book offers the first cross-comparative analysis of what intelligence agencies need to focus on in responding more effectively to future emerging health and biological security threats risks and hazards post-COVID-19. The volume addresses three principal issues. First, it investigates what roles the Five Eyes intelligence communities played (along with other key stakeholders, such as public health agencies) in managing the COVID-19 pandemic. Second, it assesses the challenges of and lessons learnt from these intelligence communities’ engagement in managing aspects of the pandemic. Third, it explores how the Five Eyes might play more effective roles in managing future health security threats and risks, whether those are intentional (bioterrorism and bio crimes), accidental (laboratory releases) or unintentional (pandemics) in origin. Overall, this book offers a coherent and holistic research agenda that seeks to improve understanding about the role of national security intelligence in managing health security threats and risks post-COVID-19. This book will be of much interest to students of intelligence studies, health security, public health and International Relations. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

Après l’ouvrage consacré aux Miroirs et jeux de miroirs paru en 2003, voici un livre tourné vers un autre objet du quotidien, intéressant tant pour l’histoire des mentalités que pour sa symbolique : la clef. La clef met en effet en œuvre des structures d’opposition entre espace clos et ouvert, intérieur et extérieur, masculin et féminin, mais aussi entre visible et caché, permis ou interdit, dont l’enjeu est souvent le pouvoir et le savoir. Cet objet banal et assez discret dans les textes du Moyen Âge, se fait aussi l’emblème possible d’une démarche d’interprétation et de lecture sous la forme d’un décryptage, qu’elle concerne le récit merveilleux, le texte allégorique, biblique ou prophétique, ou encore la transcription musicale. Le recueil, articulé en cinq sections et ponctué d’extraits de textes médiévaux, propose une exploration des emplois métaphoriques, symboliques et initiatiques des clefs mais aussi une réflexion sur la question de l’interprétation à travers un corpus varié : romans arthuriens ou non, récit de voyage dans l’au-delà, écrits allégoriques de Christine de Pizan, chansons de geste, nouvelles, pièces de théâtre, textes bibliques ou prophéties de Merlin.