Open Access Books

Welchen Beitrag kann die Diplomatik zur Erforschung der Geschichte religiöser Gemeinschaften im Mittelalter leisten – und welche neuen Perspektiven eröffnen digitale Methoden? Diesen Fragen widmete sich eine internationale Tagung, die im Mai 2024 im Rahmen des FWF-ANR-Forschungsprojekts BeCoRe (Between Composition and Reception. The Authority of Medieval Charters) in Klosterneuburg stattfand. Die Beiträge dieses Sammelbandes zeigen anhand exemplarischer Fallstudien, wie sich durch die Analyse von Urkunden und anderen Formen (spät-)mittelalterlicher Schriftlichkeit – teils gestützt auf digitale Werkzeuge – neue Einsichten in die Geschichte religiöser Gemeinschaften gewinnen lassen.

Winter is not the best time for miltary operations. It is necessary when political situation or international agreements are contained. In 1919 and 1920 Polish Army has served in Lithuania and Latvia in winter time. In Lithuania the soldiers have practiced patrol and garrison duty on polish-lithuanian border. In the same time other polish units have taken part in military operation in Latvia. There were the common features of these mission: winter, snow, low temperatures. In these circumstances the duty was much difficult. What else, the soldiers have fallen ill like cold and frost-bites.

Che cosa fu il tiranno e che cos’è la tirannide? Come restituire problematicità speculativa a queste due nozioni usurate da indeterminatezza e discredito? I saggi della prima parte di questo volume indagano il senso della tirannide attraverso la ripresa di otto figure decisive: la coppia archetipica Giobbe-Edipo, il momento-Machiavelli, l’Illuminismo francese, Weber, Heidegger, Voegelin, Hayek e Aron. La seconda parte ricostruisce, a partire da testi inediti, lo scenario del classico dibattito che vide protagonisti Strauss e Kojève. Ad integrazione di tali indagini viene proposta la traduzione di due saggi di Strauss e Fessard, ed una bibliografia aggiornata.

The contributions of this volume, celebrating the 50th anniversary of Institut für deutsche Sprache, discuss current trends in grammar research and grammaticography, lexicology and lexicography, spoken language research, as well as corpus and computer linguistics. In addition, they provide an overview of the current status of linguistic research and possible new fields of investigation.

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.

This research addresses the need to manage student diversity and academic trajectories in higher education through personalized learning, overcoming the risks of algorithmic reductionism and decontextualized automation that depersonalize the educational process. Through an applied instructional design approach and a systematic review of the technical literature, this study proposes and substantiates the architecture of an intelligent hybrid model that coherently articulates and integrates massive analytical data sources from learning management systems (LMS), educational ontologies, explicit pedagogical rules, and machine learning algorithms. The conceptual results demonstrate that the development and implementation of adaptive environments and intelligent tutors make it possible to model dynamic student profiles and structure flexible learning paths that continuously adjust according to students’ achievement levels. In this context, we successfully designed highly efficient early-warning systems based on data mining that promptly identify signs of academic risk and vulnerability, thereby significantly reducing dropout rates and enhancing student retention. It is concluded that the true effectiveness of intelligent hybrid models is not limited to their metric or predictive accuracy, but rather lies substantially in active faculty mediation, algorithmic transparency, decision explainability, and ethical and institutional governance of information. Technological personalization gains viability and social value only when it is established as a tool aimed at strengthening equity, inclusion, and informed human decision-making within the university ecosystem.

Unter Einbezug relevanter Studien und zahlreicher Aspekte wie Wertewandel, geänderte Bildungserfordernisse, Einfluss von und Umgang mit Medien und Technik geht Hans Lenk dem sich wandelnden Arbeitsbegriff nach. Er plädiert dafür, das von den Vereinten Nationen formulierte Recht auf Arbeit weiterzuentwickeln zu einem Recht auf Eigenleistung und persönliche Entwicklung und formuliert einschlägige Thesen zum Wandel des Arbeitsbegriffs die den Bedingungen der postindustriellen Arbeit Rechnung tragen.

In health research, approaches based on biomedical and epidemiological studies fail to capture the complexity of population health interventions. Yet it is essential to study them using approaches adapted to their complexity, the plurality of their mechanisms, and the diversity of local actors and contexts. This is the purpose of population health intervention research (PHIR), as summarized in this book. Through conceptual and methodological explanations, and illustrations of numerous examples from around the world, the authors aim to address a need for training in this scientific approach among researchers and, more broadly, healthcare professionals, by examining essential issues of effectiveness, equity, relevance, implementation, and scaling-up.

The kitchen is the core~it is the heart of the home. A major part of our daily routine takes place in the kitchen. In addition to being a place for food preparation, the kitchen also defines our lifestyle and social status. In the 20th century, the kitchen, its practices and representations were changing. The form, use and purpose of the kitchen were connected to general and specific (micro-)regional economic, social, demographic, cultural and ideological circumstances, and after all also socio-economic conditions of the household. This book ('From the main place to dwell to a working cell: Development of the kitchen in the Vipava Valley') presents the formal development of the kitchen in the Vipava Valley in the 20th century regarding the changes in kitchen practices and the image of the kitchen.

Une gigantesque révolte parcourt la Flandre, le Hainaut et l’Artois de 1565 à 1569. Des nobles se liguent et manifestent contre la politique menée par Philippe II, roi d’Espagne, et ses ministres. Ils sont traités de Gueux et revendiquent fièrement ce qualificatif. Simultanément les « sectaires », terme qui désigne alors les protestants, de plus en plus nombreux, dévastent près de 400 églises en quelques jours. C’est l’iconoclasme de l’« Année des Merveilles » (1566). « Vive les Gueux » est le cri de ralliement des contestataires du pouvoir, puissants en Flandre, à Valenciennes et au Cateau-Cambrésis. Philippe II refuse de pactiser avec les rebelles et de voir la nouvelle religion coexister avec le catholicisme. Il envoie les troupes d’élite de l’armée espagnole conduites par le duc d’Albe pour châtier les « Flamencos ». Par le glaive, par la corde, par le feu, des centaines de révoltés sont exécutés. Le comte d’Egmont est décapité. Quelques milliers de familles fuient, sont bannies à perpétuité et leurs biens sont confisqués. À partir des documents d’archives, de manuscrits, d’imprimés d’époque, et de travaux universitaires, Alain Lottin retrace cette histoire tragique et souvent méconnue en France dans ce livre abondamment illustré de gravures, dessins, cartes et gouaches d’époque.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disorder. It is characterized by progressive, bilateral renal cystic expansion followed by gradual loss of renal function after decades of life, while its systemic nature is reflected by extra-renal manifestations typically involving liver and the cardiovascular system. Cyst formation is triggered by mutations in the PKD1 or PKD2 genes. In most cysts, if not all, cystogenesis follows a two-hit model in developmental kidneys, while in the mature organ broad and fast cyst formation requires a third hit such as kidney injury. The first hit is represented by the germline mutation whereas a somatic total or partial inactivation of the previously normal allele constitutes the second event, a process that is consistent with the focal nature of ADPKD cystogenesis. PKD1 encodes polycystin-1 (PC1), a likely transmembrane mechano-sensor receptor comprised of a singular combination of structural domains present in other proteins. PKD2, in turn, encodes polycystin-2 (PC2), a non-selective cationic channel permeable to calcium composed by six transmembrane helices and intracytosolic C- and N-termini. In the primary cilium, PC1 regulates cell calcium influx by physically interacting with PC2 through their intracytosolic domains. Disruption of calcium cellular homeostasis increases cAMP cytosolic levels and affects cell cycle, leading to increased cell proliferation and transepithelial fluid secretion. In addition, disruption of PC1 C-terminus interactions with components of Wnt, mTOR, STAT3 and JAK2/STAT1 pathways is translated into a number of intracellular pathway abnormalities. In the same line, interactions between the PC2 C- and N-termini with ERK/B-Raf, GSK3β and other partners lead to disturbed cell proliferation, apoptosis and cell polarity. Mutations in PKD1 can result, moreover, in cell adhesion and extracellular matrix alterations, due to the role of PC1 extracellular domains in cell-cell and cell-matrix contact. Defects in the mentioned pathways can also impact oriented cell division, contributing to cyst growth.

What does effective research and development look like in the creative industries and how might it lead to successful innovation? This book is an answer to that question. Building upon place-based creative industry research, the book focuses on evidence from the media sector, while encompassing a range of creative practices, from digital tourism to dance. Leveraging unique empirical data from the Welsh creative industries, the authors map a series of pathways for creative businesses. In so doing, the book offers new frameworks for assessing innovative practice and highlights options for tailored institutional funding. Channelling research insights, this shortform book helps researchers, policy-makers and reflective practitioners to understand how to deliver effective strategies for the creative sector. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

L'époque contemporaine connaît une expansion générale de l'offre scolaire, effet de politiques éducatives relativement ambitieuses. Toutefois, la mise en place d'appareils spécifiques ne débouche pas sur une scolarisation effective de la jeunesse. Seule une approche comparée des diverses réalités locales, telle celle qui est tentée ici, peut espérer rendre compte des modalités concrètes d'application du modèle commun. La diversité des sources et des méthodes utilisées, propre à un colloque ou...