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Most mouse kidney stone models induce nephrocalcinosis rather than urolithiasis. The aim of our study was to find an accelerated experimental model in order to study the early events of stone formation, that is, at the t...
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By following the evolution of populations that are initially genetically homogeneous, much can be learned about core biological principles. For example, it allows for detailed studies of the rate of emergence of de novo ...
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Endoplasmic Reticulum (ER) stress of alveolar epithelial cells (AECs) is recognized as a key event of cell dysfunction in pulmonary fibrosis (PF). However, the mechanisms leading to AECs ER stress and ensuing unfolded pr...
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El director italiano Ermanno Olmi comenzó su carrera cinematográfica rea- lizando películas para la empresa hidroeléctrica Edison Volta, de la que era empleado, durante los años cincuenta. Siguiendo las líneas teóricas d...
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A multi-leader-follower game (MLFG) model for the design of the utility network in an eco-industrial park (EIP) is studied and implemented by introducing the concept of an environmental authority. The methodology also co...
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Background: Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory f...
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Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein. Mutated hungtingtin, although widely expressed in the brain, predominant...
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Succinate dehydrogenase subunit B and D (SDHB and SDHD) mutations represent the most frequent cause of hereditary pheochromocytoma and paraganglioma (PPGL). Although truncation of the succinate dehydrogenase complex is t...
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Germany is well known around the world for the strength of its economy, its industry and for the "German model" for higher engineering education based on developing technological skills at a very high level. In this arti...
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Given a Linear Time Invariant (LTI) system with parametric uncertainties, we propose a new method to synthesize a structured controller with H infinity constraints. Our approach is based on global optimization. The probl...
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Introduction : Les nuisances sonores en réanimation sont diverses, émanant de l'activité continue du service et peuvent atteindre un niveau de décibels élevé. Le bruit a un impact néfaste sur les patients et le personnel...
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The use of constitutive equations calibrated from data has been implemented into standard numerical solvers for successfully addressing a variety problems encountered in simulation-based engineering sciences (SBES). Howe...
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The recent French “Energy transition act” has set stringent targets to increase the share of renewables in the French electricity mix. In this context, this study aims at quantifying the requirements for steel, aluminium...
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Contexte : Un programme d’amélioration de la qualité des soins est implémenté depuis 2011 en France dans la filière mucoviscidose en adaptant la démarche qualité collaborative développée aux USA par la Cystic Fibrosis Fo...