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Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Yi-Shan Jiang, Hong Shi, Yu-Ting Kang, Ji Shen et al. • BMC Geriatrics (2023)

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-04089-5

ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

Diletta Fontana, Mario Mauri, Rossella Renso, Mattia Docci et al. • Nature Communications (2020)

ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon p...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-020-19721-w

Lipid profile in elderly and centenarian subjects in Kazakhstan: a case-control study

Yu. Ganzhula, Zh. Borykbay, V. Tkachev, S. Urazova et al. • Central Asian Journal of Medical Hypotheses and Ethics (2024)

Introduction. The health of centenarians is a major focus in global studies. Dyslipidemia is directly linked to the risk of cardiovascular diseases, which pose a growing burden on healthcare due to the increasing elderly population. Studyin...

DOAJ Open Access (DOAJ) DOI: 10.47316/cajmhe.2024.5.3.04

Health technology innovations

R. F. L. Azevedo • Gerontechnology (2022)

The global pandemic has drastically impacted older adults in numerous ways (e.g., loneliness; age discrimination; mental and physical health; limited access to traditional health care).On the other hand, it may have accelerated the general ...

OPENALEX cc-by DOI: https://doi.org/10.4017/gt.2022.21.s.593.sp3

Lipidomic Analysis of Caenorhabditis elegans Embryos

Hung-Chi Yang, Cheng-Yu Hung, Yi-Yun Pan, Szecheng Lo et al. • Bio-Protocol (2017)

Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal m...

DOAJ Open Access (DOAJ) DOI: 10.21769/BioProtoc.2554

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst et al. • Genome Medicine (2020)

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected indiv...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13073-020-00749-y