ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

Journal: Nature Communications • • Nature Portfolio • ISSN: 2041-1723

Abstract

ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.

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How to Cite this Article

Diletta Fontana, Mario Mauri, Rossella Renso, et al. (2020). "ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine". Nature Communications. https://doi.org/10.1038/s41467-020-19721-w