Academic Articles & Research Papers

Low Pathogenic Avian Influenza H9N2 Viruses in Morocco: Antigenic and Molecular Evolution from 2021 to 2023

Avian influenza viruses pose significant threats to both the poultry industry and public health worldwide. Among them, the H9N2 subtype has gained substantial attention due to its high prevalence, especially in Asia, the Middle East, and Af...

USP1-trapping lesions as a source of DNA replication stress and genomic instability

Here the authors provide mechanistic insights into how auto-cleavage of the USP1 deubiquitinase regulates DNA replication and genome stability. Implications for the targeting of USP1 activity via protein-DNA trapping in cancer therapy are d...

P2′ Site Scanning of Snake Kunitz-Type Toxin Analogue BF9-N17H with Unique P1 Site Histidine Highlights Novel XIa Inhibitory Peptides Without Plasmin Inhibitory Activity

Kunitz-type peptides from venomous and blood-sucking animals represent an important natural molecular resource for anticoagulant development towards XIa, a new target for antithrombotic drug discovery. However, the plasmin-inhibitory activi...

β-Cell Death in Diabetes: Past Discoveries, Present Understanding, and Potential Future Advances

β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and potential future advances in our understanding of the m...

Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity

Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemio...

Transcriptome analysis of Crossostephium chinensis provides insight into the molecular basis of salinity stress responses.

Soil salinization is becoming a limitation to the utilization of ornamental plants worldwide. Crossostephium chinensis (Linnaeus) Makino is often cultivated along the southeast coast of China for its desirable ornamental qualities and high ...

Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome

Abstract Background Human exposure to high doses of radiation resulting in acute radiation syndrome and death can rapidly escalate to a mass casualty catastrophe in the event of nuclear accidents or terrorism. The primary reason is that the...

A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss

Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to human SELENON-related myopathies. SelenoN knockout (KO) mouse limb muscles, however, are protected from the disease, and display no major alt...

Unraveling genetic diversity in ‘Foşa’ and ‘Yomra’ hazelnut accessions (Corylus avellana L.) using SSR markers and phenotypic analysis

Abstract The Foşa hazelnut variety is commonly cultivated in Türkiye and is often confused with the Yomra variety due to morphological similarities. This study aims to determine the phenological and pomological characteristics of the Foşa a...

The Role of Mast Cells and Their Potential as a Therapeutic Target For Neuroinflammation

Sarah Adriana Scuderi,1 Rossella Basilotta,2 Laura Cucinotta,2 Alessio Ardizzone,3 Emanuela Esposito21Genetics and Pharmacogenetics Unit, ‘Gaetano Martino’ University Hospital, Messina, Italy; 2Department of Chemical, Biological, Pharmaceut...

Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study

Background The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease ...

Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke

Background: Ischemic stroke is one of the serious complications of diabetes. Non-coding RNAs are established as promising biomarkers for diabetes and its complications. The present research investigated the expression profiles of serum TUG1...

High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia

Abstract Background Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity, respectively. There has been no information on the status of co-infections of tuberculosis a...

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-spec...

A history of molecular biology

Molecular biology of the cell

MOLECULAR BIOLOGY OF THE MYCOBACTERIA

The molecular biology of the mycobacteria is poised at the threshold of making major contributions to the understanding of the biochemistry and pathogenic mechanisms involved in mycobacterial infections.The application of molecular biology ...

Graphs in molecular biology

Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology. We d...

Molecular biology of flaviviruses

The molecular biology of cyanobacteria