Academic Articles & Research Papers

Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 ...

HEART Camp Connect—Promoting adherence to exercise in adults with heart failure with preserved ejection fraction

Abstract Aims Most adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF)....

Music therapy-induced changes in salivary cortisol level are predictive of cardiovascular mortality in patients under maintenance hemodialysis

Yi-Chou Hou,1 Yen-Ju Lin,2 Kuo-Cheng Lu,1 Han-Sun Chiang,3 Chia-Chi Chang,4 Li-King Yang1 1Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 2Department of Nursing, Taipei Medical Univ...

Features of the electrolyte distribution in various tissues in miniature pigs

Striking similarities between human and miniature pig anatomy and physiology of the cardiovascular system, skin and digestive organs have made miniature pigs a successful animal model for addressing problems of xenotransplantation. However,...

miR-3113-5p, miR-223-3p, miR-133a-3p, and miR-499a-5p are sensitive biomarkers to diagnose sudden cardiac death

Abstract Background Sudden cardiac death (SCD) remains a great health threat and diagnostic challenge, especially those cases without positive autopsy findings. Molecular biomarkers have been urgently needed for the diagnosis of SCD display...

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?

Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considere...

Evaluation of clinical quality improvement interventions: feasibility of an integrated approach

Abstract Background Cardiovascular diseases (CVD) are the largest cause of death and disability in Australia. Australian national guidelines for the primary prevention of CVD recommend that all adults without CVD and aged 45 years or more a...

Lipid profile in elderly and centenarian subjects in Kazakhstan: a case-control study

Introduction. The health of centenarians is a major focus in global studies. Dyslipidemia is directly linked to the risk of cardiovascular diseases, which pose a growing burden on healthcare due to the increasing elderly population. Studyin...

Cardiovascular Mathematics

Demographic changes and the need for health technology

Discussion focusses on recent trends in demand, giving consideration to how these trends might change between now and the end of the century. Attention is directed to the UK, but to put the situation in perspective a brief review of the wor...

Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study

IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the exis...

Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016

Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid...

The evolution of digital health technologies in cardiovascular disease research

When implemented in practice, digital technologies have shown improvements in morbidity and mortality outcomes in patients with cardiovascular disease (CVD). For scholars, research into digital technologies in cardiovascular care has been r...

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Abstract The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies. Here, we present a cardiac innervation-on-a-c...

Healthy lifestyle attenuates the clonal hematopoiesis-associated coronary artery disease risk

Lifestyle factors and clonal hematopoiesis of indeterminate potential (CHIP) both contribute to the risk of developing coronary artery disease (CAD), but whether a healthy lifestyle could attenuate CHIP-related CAD risk is unknown. A total ...

Health Technology Assessment for Cardiovascular Digital Health Technologies and Artificial Intelligence: Why Is It Different?

Introduction to Health Technology Assessment

Abstract The objective of this review is to introduce the readers of this journal to the knowledge of some basic aspects of Health Technology Assessment (HTA). HTA starts from the need of the “political governance” to provide adequate healt...

Evaluation of Lens Doses among Medical Staff Involved in Nuclear Medicine: Current Eye Radiation Exposure among Nuclear-Medicine Staff

The International Commission on Radiological Protection has lowered the annual equivalent eye-lens dose to 20 mSv. Although occupational exposure can be high in nuclear medicine (NM) departments, few studies have been conducted regarding ey...

Development and validation of an interpretable machine learning model for predicting the risk of coronary heart disease risk in diabetes mellitus patients: a dual-center retrospective study

Abstract Background Diabetes mellitus (DM) combined with coronary heart disease (CHD) significantly increases the risk of cardiovascular events with a greater mortality rate. Therefore, establishing a predictive model can help DM patients r...

A Focus on Simulation in Medical Informatics

This special issue of JAMIA addresses simulation, a methodology that holds great promise for the advancement of information technology in health care. Simulation has been termed a third domain, complementing both natural language and mathem...