Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

Ying Li; Ying Li; Na Jia; Xinyue Li; Jingwen Dai; Deping Liu; Deping Liu

doi:10.3389/fcvm.2026.1753832

Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

Ying Li (Peking University Fifth School of Clinical Medicine, Beijing, China) Ying Li (Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China) Na Jia (Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China) Xinyue Li (Department of General Practice, Taihu Community Health Service Center, Beijing, China) Jingwen Dai (Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China) Deping Liu (Peking University Fifth School of Clinical Medicine, Beijing, China) Deping Liu (Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China)

Journal: Frontiers in Cardiovascular Medicine • 2026-04-01 • Frontiers Media S.A. • ISSN: 2297-055X

Abstract

This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 gene (c.3343G> A: p.Val1115Ile). Despite optimal medical therapy and implantable cardioverter-defibrillator (ICD) implantation, the patient developed progressive cardiac dysfunction and recurrent ICD shocks. We discuss the clinical course, genetic findings, and imaging features of this case.

Subjects & Keywords

# Diseases of the circulatory (Cardiovascular) system # hypertrophic cardiomyopathy # left ventricular apical aneurysm # left ventricular excessive trabeculation # MYBPC3 # ventricular arrhythmia

How to Cite this Article

                    Ying Li, Ying Li, Na Jia, et al. (2026). "Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report". Frontiers in Cardiovascular Medicine. https://doi.org/10.3389/fcvm.2026.1753832                

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Identifiers & Provenance

DOI: 10.3389/fcvm.2026.1753832 ↗
Primary Index: DOAJ