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Optimization of GDMT for patients with heart failure and reduced ejection fraction: can physiological and biological barriers explain the gaps in adherence to heart failure guidelines?

Marilyne Jarjour, Anique Ducharme • Drugs in Context (2023)

Heart failure is a growing epidemic with high mortality rates and recurrent hospital admissions that creates a burden on affected individuals, their caregivers and the whole healthcare system. Throughout the years, many randomized trials ha...

DOAJ Open Access (DOAJ) DOI: 10.7573/dic.2023-5-6

Mpox as Two Global Health Emergencies: Altered Transmission, Genomics, Clinical Manifestation and Public Health Impact

Sanchita Chakraborty, S.R. Rao, Abhijit Poddar • Infectious Microbes & Diseases (2025)

Mpox virus (MPXV) is the only pathogen that triggered two Public Health Emergency of International Concern (PHEIC) declarations, first in July 2022 and then again in August 2024. The 2022 outbreak was attributed primarily to clade IIb MPXV,...

DOAJ Open Access (DOAJ) DOI: 10.1097/IM9.0000000000000196

Gestão do trabalho, da educação, da informação e comunicação na atenção básica à saúde de municípios das regiões Sul e Nordeste do Brasil Management of work, education, information, and communication in primary healthcare in cities in Southern and Northeastern Brazil

Denise Silva da Silveira, Luiz Augusto Facchini, Fernando Vinholes Siqueira, Roberto Xavier Piccini et al. • Cadernos de Saúde Pública (2010)

A descentralização das ações no Sistema Único de Saúde requer competências específicas para a gestão municipal. As demandas incluem o gerenciamento de equipes de trabalho, estrutura física e tecnológica, e organização de insumos e estratégi...

DOAJ Open Access (DOAJ) DOI: 10.1590/S0102-311X2010000900005

Associated Factors of Pre-Anesthesia Blood Pressure Elevation in Elective Non-Cardiac Surgical Patients: A Case-Control Study Comparing Two Diagnostic Thresholds

Li XM, Yang Y, Pan H, Li W et al. • Risk Management and Healthcare Policy (2026)

Xiao-Min Li,1 Yan Yang,1 Hao Pan,2 Wang Li,2 Ge-Yi Ai,2 Xi-Jiang Liu,2 Guang-Fen Zhang,2 Jie Guo31Department of Anesthesiology, Zibo Central Hospital, Zibo, People’s Republic of China; 2Department of Anesthesiology, Shandong Provincial Hosp...

DOAJ Open Access (DOAJ)

Chimeric antigen receptor T‐cell therapy: Challenges and framework of outpatient administration

Katie S. Gatwood, Bhagirathbhai R. Dholaria, Mariana Lucena, Brittney Baer et al. • eJHaem (2022)

Abstract Adoptive cellular therapy has made a landmark change within the treatment paradigm of several hematologic malignancies, and novel cellular therapy products, such as chimeric antigen receptor T‐cell therapy (CART), have demonstrated...

DOAJ Open Access (DOAJ) DOI: 10.1002/jha2.333

Physicochemical- and biocompatibility of oxygen and nitrogen plasma treatment using a PLA scaffold

Ali Davoodi, Homayoun H. Zadeh, Morteza Daliri Joupari, Mohammad Ali Sahebalzamani et al. • AIP Advances (2020)

Plasma surface treatment has a wide range of applications in biomedicine. In the present study, flat polylactic acid (PLA) films were treated with oxygen and nitrogen, low-pressure, non-thermal plasma. The water contact angle of the PLA fil...

DOAJ Open Access (DOAJ) DOI: 10.1063/5.0022306

State of the Art and Environmental Aspects of Plant Microbial Fuel Cells’ Application

Roman Lepikash, Daria Lavrova, Devard Stom, Valery Meshalkin et al. • Energies (2024)

Environmental pollution is becoming ubiquitous; it has a negative impact on ecosystem diversity and worsens the quality of human life. This review discusses the possibility of applying the plant microbial fuel cells (PMFCs) technology for c...

DOAJ Open Access (DOAJ) DOI: 10.3390/en17030752

Antioxidant, Wound Healing Potential and In Silico Assessment of Naringin, Eicosane and Octacosane

Abbirami Balachandran, Sy Bing Choi, Morak-Młodawska Beata, Jeleń Małgorzata et al. • Molecules (2023)

1. Diabetic chronic wounds, mainly foot ulcers, constitute one of the most common complications of poorly managed diabetes mellitus. The most typical reasons are insufficient glycemic management, latent neuropathy, peripheral vascular disea...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28031043

Antibiogram Profile and Resistance Patterns of Microflora from Vaginal Discharge in Reproductive-age Women at a Nigerian Teaching Hospital

Chizoba M. Enemchukwu, Christiana Nwabueze, Oluchi J. Osuala, Chinedu J. Ikem et al. • RADS Journal of Biological Research & Applied Science (2024)

Background: The adult human vagina hosts a complex biota containing diverse communities of microorganisms. The occurrence of multi-drug-resistant strains of these microorganisms has persistently increased due to poor hygiene and misuse or a...

DOAJ Open Access (DOAJ)

The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology

Jean-Étienne R. L. Morlighem, Chen Huang, Qiwen Liao, Paula Braga Gomes et al. • Marine Drugs (2018)

Marine invertebrates, such as sponges, tunicates and cnidarians (zoantharians and scleractinian corals), form functional assemblages, known as holobionts, with numerous microbes. This type of species-specific symbiotic association can be a ...

DOAJ Open Access (DOAJ) DOI: 10.3390/md16060207

Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics

Eliza Williams, Jeremy Altman, Saleh Ahmed, Garrett Jones et al. • BMC Ophthalmology (2025)

Abstract Background Alterations in the constituents of the aqueous humor (AH) are associated with various ocular pathologies, including primary open-angle glaucoma (POAG). AH contains a variety of immunomodulatory molecules, including serin...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12886-025-04119-3

Interactions of cephalexin with bovine serum albumin: displacement reaction and molecular docking

Hamed Hamishehkar, Soheila Hosseini, Abdolhossein Naseri, Azam Safarnejad et al. • BioImpacts (2016)

Introduction: The drug-plasma protein interaction is a fundamental issue in guessing and checking the serious drug side effects related with other drugs. The purpose of this research was to study the interaction of cephalexin with bovine se...

DOAJ Open Access (DOAJ) DOI: 10.15171/bi.2016.19

Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer

Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher et al. • Molecular Cancer (2025)

Abstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). In general, endothelial cells exhibit diverse immunomodu...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-024-02221-6

A Pilot Study to Non-Invasively Track PIK3CA Mutation in Head and Neck Cancer

Henri Schmidt, Arutha Kulasinghe, Richard J.N. Allcock, Lit Yeen Tan et al. • Diagnostics (2018)

Background: PIK3CA pathways are the most frequently mutated oncogenic pathway in head and neck squamous cell carcinoma (HNSCC), including virally driven HNCs. PIK3CA is involved in the PI3K-PTEN-mTOR signalling pathway. PIK3CA has been impl...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics8040079

Structure and transport mechanism of P5B-ATPases

Ping Li, Kaituo Wang, Nina Salustros, Christina Grønberg et al. • Nature Communications (2021)

In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human A...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-021-24148-y

Emergence of Carbapenem-Resistant Enterobacteriaceae in a Tertiary Care Hospital in Southern Thailand†

Prerit Upadhyaya ARYAL, Benjamas THAMJARUNGWONG, Kamonnut SINGKHAMANAN, Paramee THONGSUKSAI et al. • Walailak Journal of Science and Technology (2020)

Carbapenem-resistant Enterobacteriaceae (CRE) is emerging as a major problem in healthcare settings globally, including Thailand, due to limited therapeutic options. We reported the detection, antimicrobial susceptibility profiles, and the ...

DOAJ Open Access (DOAJ)

Complex Abdominal Wall Hernias: Structured Use of Adjuvant Therapies

Joana Marques‐Antunes, Egon Rodrigues, Marta Guimarães, Marta Guimarães et al. • Journal of Abdominal Wall Surgery (2025)

PurposeRepairing complex abdominal wall hernias is challenging, often requiring component separation techniques (CST) for tension-free closure. Adjuvant therapies, such as botulinum toxin type A (BTA), preoperative progressive pneumoperiton...

DOAJ Open Access (DOAJ) DOI: 10.3389/jaws.2025.14515