Academic Articles & Research Papers

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer

Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets th...

Assessing Acceptance and Intention to Use of Home Telemonitoring Among Patients with Liver Cirrhosis: Development and Initial Psychometric Validation of a TAM-Based Questionnaire

Background/Objectives: Liver cirrhosis (LC) is a major cause of morbidity and mortality requiring continuous monitoring and early recognition of clinical deterioration. Home telemonitoring is increasingly considered a supportive strategy fo...

Artificial neural network–based model for sleep quality prediction for frontline medical staff during major medical assistance

Background: The sleep quality of medical staff was severely affected during COVID-19, but the factors influencing the sleep quality of frontline staff involved in medical assistance remained unclear, and screening tools for their sleep qual...

Machine learning framework for early identification of high-spending Crohn’s disease patients using administrative claims

Objectives To develop and evaluate a machine learning (ML) model that predicts Crohn’s disease (CD) patients responsible for the top quartile of healthcare spending.Methods De-identified commercial claims (2016–2018) from ~267 000 continuou...

DeltaProt: a software toolbox for comparative genomics

Abstract Background Statistical bioinformatics is the study of biological data sets obtained by new micro-technologies by means of proper statistical methods. For a better understanding of environmental adaptations of proteins, orthologous ...

A pairwise residue contact area-based mean force potential for discrimination of native protein structure

Abstract Background Considering energy function to detect a correct protein fold from incorrect ones is very important for protein structure prediction and protein folding. Knowledge-based mean force potentials are certainly the most popula...

Health and Medical Informatics Education

Health and medical informatics education has meanwhile gained considerable importance for medicine and for health care. Specialized programs in health/medical informatics have therefore been established within the last decades. This special...

A Virtual Reading Center Model Using Crowdsourcing to Grade Photographs for Trachoma: Validation Study

BackgroundAs trachoma is eliminated, skilled field graders become less adept at correctly identifying active disease (trachomatous inflammation—follicular [TF]). Deciding if trachoma has been eliminated from a district or if treatment strat...

Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support

Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological subtype, and molecular alterations. Re...

Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation

Abstract Background Lipedema is an adipose tissue disorder involving mostly women. One of the most characteristic lipedema symptoms is painful accumulation of adipose tissue in lower and upper extremities leading to disproportion. Due to th...

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity

Abstract Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the $$S/F$...

Medical Informatics and Education

Medical Informatics: An Introduction

1. Information Processing in Medicine.- 1.1 Introduction.- 1.2 Overlap With Other Disciplines.- 2. Informatics.- 2.1 Structure.- 2.2 Fundamental Concepts.- 2.2.1 Message and Information.- 2.2.1.1 Events, Probability.- 2.2.1.2 SHANNON'S Info...

Medical Informatics in a United and Healthy Europe

CONFLICT OF INTEREST: NONE DECLARED...

Wrist movements induce torque and lever force in the scaphoid: an ex vivo study

Abstract Purpose We hypothesised that intercarpal K-wire fixation of adjacent carpal bones would reduce torque and lever force within a fractured scaphoid bone. Methods In eight cadaver wrists, a scaphoid osteotomy was stabilised using a lo...

Statistical data for the tensile properties and static fatigue of sic-based bundles

Due to their high specific strength at elevated temperatures and resistance to oxidative environments, SiC-based fibers are of great interest for the reinforcement of ceramic matrix composites. They are however subjected to a slow crack gro...

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

Real-World Evaluation of AI-Driven Diabetic Retinopathy Screening in Public Health Settings: Validation and Implementation Study

Abstract BackgroundArtificial intelligence (AI) algorithms offer an effective solution to alleviate the burden of diabetic retinopathy (DR) screening in public health settings. However, there are challenges in translating diagno...

Digital quality gradient and the burden of elderly depression: A spatial multi kernel SVR analysis of socio economically vulnerable groups in England

Digital infrastructure is increasingly understood as part of the contemporary built environment and as a policy-relevant area-level correlate of older adults’ mental health. Existing studies have often relied on linear models and have paid ...

Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress

We present the data for taurine (2-aminoethanesulfonic acid) treatment to healthy pregnant Sprague Dawley rats (SD). At embryonic day 15 (E15), healthy pregnant SD rats were given taurine treatment (50 mg/L drinking water) and then to their...