Academic Articles & Research Papers

Beyond Lymphocytic Inflammation: Immune Architecture as a Determinant of Renal Outcomes

EFFECT OF VITAMIN A ON CYCLOSPORINE NEPHROTOXICITY IN UNINEPHRECTOMIZED RATS

The influence of vitamin A (1.5 mg kg-1 body weight) administration for two weeks on cyclosporine A (CsA, 25 mg kg-1 body weight) induced renal dysfunction has been investigated in uninephrectomized and sham nephrectomized rats. Single kidn...

Molecular Dynamics and In Vitro Studies Elucidating the Tunable Features of Reconfigurable Nanodiscs for Guiding the Optimal Design of Curcumin Formulation

In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We ...

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic ...

Perspective on the Therapeutics of Anti-Snake Venom

Snakebite envenomation is a life-threatening disease that was recently re-included as a neglected tropical disease (NTD), affecting millions of people in tropical and subtropical areas of the world. Improvement in the therapeutic approaches...

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

ID241 Ampliando a Participação Social nas Consultas Públicas da CONITEC: Uma Análise da Opinião da Sociedade

Introdução Este estudo analisou a participação social nas consultas públicas promovidas pela CONITEC (Comissão Nacional de Incorporação de Tecnologias no Sistema Único de Saúde) com o objetivo de promover a equidade no acesso a tecnologias ...

Role of pyroptosis in spinal cord injury and its therapeutic implications

Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosi...

Fumaric acid regulates morphine tolerance in bone cancer pain through spinal MrgC receptor modulation

Background: Bone cancer pain (BCP) represents a debilitating complication that profoundly impacts patient quality of life and predisposes to psychological comorbidities, including depression and anxiety. Objectives: To investigate the effec...

Enteric Coating Enhances the Biopharmaceutical Performance of a Silica–Lipid Formulation of Abiraterone Acetate

Background/Objectives: Lipid-based formulations are widely used to enhance the oral bioavailability of poorly water-soluble drugs. However, for weakly basic drugs with higher solubility under acidic conditions, precipitation and recrystalli...

ANTIOXIDANT ACTIVITY DETERMINATION IN A LIPIDIC PEROXIDATION MODEL OF BUTTER INHIBITED BY ISOESPINTANOL

The antioxidant activity (Φ) is defined as the slope of the simple linear regression of φ0/φi against the concentration μM, in an inhibition model of lipid peroxidation of butter at 60° C, where φi is the concentration effect of isoespintan...

Caracterização dos medicamentos descartados no ponto de coleta em uma universidade do nordeste brasileiro

Objetivo: analisar o perfil pós-consumo dos medicamentos descartados pela comunidade universitária no coletor disponibilizado no Centro de Ciências da Saúde da Universidade Federal da Paraíba. Métodos: O projeto de extensão Descarta CIM ins...

Relative Stability of cis- and trans-Hydrindanones

The relative stabilities of several cis- and trans-hydrindanones were compared using both isomerization experiments and MM2 calculations. The generally believed rule that cis-hydrindanones are more stable than trans-isomers is applicable, b...

INTERAÇÕES PLANTA MEDICINAL X MEDICAMENTO CONVENCIONAL NO TRATAMENTO DA HIPERTENSÃO ARTERIAL

A hipertensão arterial sistêmica, dentre as doenças crônicas, apresenta-se como um dos problemas de saúde de maior magnitude na atualidade, sendo uma das principais causas de morbidade e mortalidade cardiovascular no Brasil. Seu tratamento ...

Comparison of Vitamin B1 (Thiamin hydrochloride) Level in Brown Rice (Oryza nivara S.D.Sharma & Shastry) and Cooked Brown Rice by Alkalimetry Methods

Brown rice (Oryza nivara S.D.Sharma & Shastry) is a rice variety that belongs to the Graminae family. Brown rice contains vitamins A, B, C, Zn and B complex. Vitamin B1 is one type of vitamin that is not stable. Its stability is influenced ...

Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis

An amendment to this paper has been published and can be accessed via a link at the top of the paper....

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

Palladium-Catalyzed Stereoselective Construction of 1,3-Stereocenters Displaying Axial and Central Chirality via Asymmetric Alkylations

The concurrent construction of 1,3-stereocenters remains a challenge. Herein, we report the development of stereoselective union of a point chiral center with allenyl axial chirality in 1,3-position by Pd-catalyzed asymmetric allenylic alky...

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Lesetja J Legoabe,1 Anél Petzer,1 Jacobus P Petzer1,21Centre of Excellence for Pharmaceutical Sciences, 2Department of Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, South AfricaAbstract: Based on...