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ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

Diletta Fontana, Mario Mauri, Rossella Renso, Mattia Docci et al. • Nature Communications (2020)

ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon p...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-020-19721-w

Diet in 1-year-old farm and control children and allergy development: results from the FARMFLORA birth cohort

Karin Jonsson, My Green, Malin Barman, Agneta Sjöberg et al. • Food & Nutrition Research (2016)

Background: A farming environment confers strong protection against allergy development. We have previously shown that farming mothers consume more full-fat dairy than control mothers, who instead consume more low-fat dairy, margarine, and ...

DOAJ Open Access (DOAJ) DOI: 10.3402/fnr.v60.32721

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

Irfa Anwar, Farheen Badrealam Khan, Sajid Maqsood, Mohammed Akli Ayoub et al. • Frontiers in Nutrition (2022)

Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and c...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.819278

Beverage Consumption Patterns and Their Association with Metabolic Health in Adults from Families at High Risk for Type 2 Diabetes in Europe—The Feel4Diabetes Study

Paris Kantaras, Niki Mourouti, Theodora Mouratidou, Ekaterini Chatzaki et al. • Endocrines (2024)

In total, 3274 adults (65.2% females) from six European countries were included in this cross-sectional analysis using data from the baseline assessment of the Feel4Diabetes study. Anthropometric, sociodemographic, dietary and behavioral da...

DOAJ Open Access (DOAJ) DOI: 10.3390/endocrines5030020

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

Eva Steinke, Eva Steinke, Eva Steinke, Olaf Sommerburg et al. • Frontiers in Medicine (2023)

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.1034290

DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

Sarah Damanti, Sarah Damanti, Lorena Citterio, Laura Zagato et al. • Frontiers in Endocrinology (2024)

BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequate...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2024.1412160

Protocol to measure human IL-6 secretion from CAR T cell-primed macrophage and monocyte lineage cells in vitro and in vivo using humanized mice

Thao Nguyen, Toshiaki Yoshikawa, Yusuke Ito, Hitomi Kasuya et al. • STAR Protocols (2024)

Summary: Chimeric antigen receptor (CAR) T cell therapy often causes serious toxicities, such as cytokine release syndrome (CRS), mainly due to interleukin-6 (IL-6) secreted by monocyte lineage cells. Here, we describe a protocol to generat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xpro.2024.103423

Evaluation of clinical quality improvement interventions: feasibility of an integrated approach

Sandeep Reddy, Kevin Mc Namara, Mary Malakellis, Tim Denton et al. • Pilot and Feasibility Studies (2019)

Abstract Background Cardiovascular diseases (CVD) are the largest cause of death and disability in Australia. Australian national guidelines for the primary prevention of CVD recommend that all adults without CVD and aged 45 years or more a...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40814-018-0386-1

Lipid profile in elderly and centenarian subjects in Kazakhstan: a case-control study

Yu. Ganzhula, Zh. Borykbay, V. Tkachev, S. Urazova et al. • Central Asian Journal of Medical Hypotheses and Ethics (2024)

Introduction. The health of centenarians is a major focus in global studies. Dyslipidemia is directly linked to the risk of cardiovascular diseases, which pose a growing burden on healthcare due to the increasing elderly population. Studyin...

DOAJ Open Access (DOAJ) DOI: 10.47316/cajmhe.2024.5.3.04

Effect of falls prevention interventions on falls and the risk factors for falls among cancer survivors: protocol for a systematic review

Lynette Mackenzie, Amanda M. Clifford, Eleanor Fallon, Joanna M. Allardyce • BMJ Open (2026)

Introduction Falls are a significant health concern and associated with cancer survivorship. Falls can result in negative psychosocial consequences for cancer survivors and economic sequelae for healthcare delivery. There are cancer-specifi...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2025-110212

Agricultural Use of Lands Affected by Deep-Seated Landslides in the Transylvanian Basin and Its Consequences on Soil Physicochemical Properties

Gheorghe Roșian, Mihai Buta, Csaba Horvath • Applied Sciences (2026)

Land leveling deep-seated landslides for agricultural use alters soil profile integrity and soil functionality. In the mid-20th century, such interventions in the Transylvanian Basin (Romania) involved grading and converting landslide bodie...

DOAJ Open Access (DOAJ) DOI: 10.3390/app16083744

NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis

Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine (2022)

PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.845129

Electrochemical Sensor for Simple and Sensitive Determination of Hydroquinone in Water Samples Using Modified Glassy Carbon Electrode

Parisa Karami-Kolmoti, Hadi Beitollahi, Sina Modiri • Biomedicines (2023)

This study addressed the use of manganese dioxide nanorods/graphene oxide nanocomposite (MnO2 NRs/GO) for modifying a glassy carbon electrode (GCE). The modified electrode (MnO2 NRs/GO/GCE) was used as an electrochemical sensor for the dete...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines11071869

Obstetric complications in children with Attention Deficit/Hyperactivity Disorder and Learning Disability

Mamatha Bhat, Natalie Grizenko, Ben-Amor L, Ridha Joober • McGill Journal of Medicine (2020)

This study aims to determine whether children with ADHD and learning disabilities (LD) have a significant history of obstetrical complications when compared to children with ADHD but without LD. Methods: Sixty-four children aged 6 to 12 yea...

DOAJ Open Access (DOAJ) DOI: 10.26443/mjm.v8i2.502

Professionalising health technology assessment in South Africa

Debjani Mueller, M Poluta, M Brand, N Mutshekwane • Southern African Journal of Public Health (2024)

Health technology encompasses interventions developed to prevent, diagnose or treat medical conditions; promote health; provide rehabilitation or organise healthcare delivery. The intervention can be a test, device, medicine, vaccine, proce...

OPENALEX cc-by-nc DOI: https://doi.org/10.7196/sajph.2024.v7i2.1875

Different Transport Behaviors between Asian Dust and Polycyclic Aromatic Hydrocarbons in Urban Areas: Monitoring in Fukuoka and Kanazawa, Japan

Kim-Oanh Pham, Akinori Hara, Jiaye Zhao, Keita Suzuki et al. • Applied Sciences (2022)

To clarify different effects of Asian dust (AD), long-range transported from Asian continent, on total suspended particles (TSP) and polycyclic aromatic hydrocarbons (PAHs) in Japan, TSP were simultaneously collected during AD periods (from...

DOAJ Open Access (DOAJ) DOI: 10.3390/app12115404