Academic Articles & Research Papers

Timing of menarche and pubertal growth patterns using the QEPS growth model

ObjectivesTo explore the timing of menarche, postmenarcheal growth, and to investigate the impact of various variables on menarcheal age and postmenarcheal and pubertal growth.Study DesignThis longitudinal community population-based study a...

Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosisResearch in context

Summary: Background: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate de...

Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission

The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of mo...

Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework

Neurological hazard assessment of industrial and pesticidal chemicals demands a substantial amount of time and resources. Caenorhabditis elegans is an established model organism in developmental biology and neuroscience. It presents an idea...

<i>Escherichia coli</i> Phylogenetic and Antimicrobial Pattern as an Indicator of Anthropogenic Impact on Threatened Freshwater Mussels

Freshwater bivalves are widely used as accumulation indicators and monitoring tools for assessing contaminant effects on different levels of biological integration. This pilot study aimed to explore the phylogenetic diversity of Escherichia...

Exploring resilience among hospital workers: a Bayesian approach

Background and importanceHealthcare professionals face significant workloads, as their roles are among the most demanding and stressful. Resilience serves as a crucial factor in helping them cope with the challenges encountered in their wor...

The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients

Impaired heart rate- and respiratory regulatory processes as a sign of an autonomic dysfunction seems to be obviously present in patients suffering from schizophrenia. Since the linear and non-linear couplings within the cardiorespiratory s...

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated...

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

Types of Skin Afferent Fibers and Spinal Opioid Receptors that Contribute to Touch-Induced Inhibition of Heart Rate Changes Evoked by Noxious Cutaneous Heat Stimulation

Background In anesthetized rats and conscious humans, a gentle touch using a soft disc covered with microcones (with a texture similar to that of a finger), but not with a flat disc, inhibits nociceptive somatocardiac reflexes. Such an inhi...

Broca’s biases in modern aphasiology

Broca’s description of aphemia signals the emergence of aphasiology as a discipline. It also marks the beginning of a long tradition of studies of right-handed patients (“Nous parlons avec l’hémisphère gauche”) with lesions in the inferior ...

Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor

Does wet-cupping therapy improve repeated sprint ability, perceived wellness, and rating of perceived exertion in young active males?

Wet-cupping therapy (WCT) is one of the oldest known medical techniques, used as a traditional and complementary therapy with a wide application all around the world for general health. Research on the effects of WCT on sports performance a...

Skills underlying mathematics: The role of executive function in the development of mathematics proficiency

The successful learning and performance of mathematics relies on a range of individual, social and educational factors. Recent research suggests that executive function skills, which include monitoring and manipulating information in mind (...

Mathematical Foundations of Neuroscience

The Mathematical Brain

The concept of numbers and the ability to recognize and process them is innate, part of everyone's intellectual apparatus whether they've had formal education or not. This instinct is not dependent on basic intelligence or general knowledge...

Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study

IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the exis...

Investigating the role of human frontal eye field in the pupil light reflex modulation by saccade planning and working memory

The pupil constricts in response to an increase in global luminance level, commonly referred to as the pupil light reflex. Recent research has shown that these reflex responses are modulated by high-level cognition. There is larger pupil co...

Neuropsychological Health Technologies

The article reveals the problem of neuropsychological technologies for maintaining, strengthening and developing human health from early to adulthood as a set of corrective and developmental measures to ensure the relationship of an optimal...

Time dynamics of symptom progression in patients with acute pancreatitis: a Dynamic Time Warping analysis

BackgroundAcute pancreatitis (AP) morbidity has been increasing in recent years. Patients with AP exhibit highly variable symptom patterns over time, posting challenges to traditional analytical methods. Dynamic Time Warping (DTW) effective...