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Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Effectiveness of music-based interventions in acute care settings for people living with dementia to reduce anxiety and enhance the care experience: A systematic review.

Victoria McArthur, Susan Everington, Martyn Patel • Archives of Gerontology and Geriatrics Plus (2024)

Introduction: Dementia is a global health priority, with an increasing percentage of overall hospital bed days occupied by people with dementia (PWD). This combined with increased demand and availability of complex scanning means that there...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2024.100087

Linking Spiritual and Religious Coping With the Quality of Life of Community-Dwelling Older Adults and Nursing Home Residents

Luciano Magalhães Vitorino BSN, MSc, Gail Low RN, BSN, MA, PhD, Lucila Amaral Carneiro Vianna PhD • Gerontology and Geriatric Medicine (2016)

Objective: This study examined the effect of Positive and Negative Spiritual and Religious Coping (SRC) upon older Brazilian’s quality of life (QOL). Method: A secondary analysis of data collected from 77 nursing home residents (NHRs; M age...

DOAJ Open Access (DOAJ) DOI: 10.1177/2333721416658140

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Yi-Shan Jiang, Hong Shi, Yu-Ting Kang, Ji Shen et al. • BMC Geriatrics (2023)

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-04089-5

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Eimear Connolly, Shane Lyons, Cliona O’Farrelly, Graham Knight et al. • BMJ Open (2023)

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2023-077772

Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults

Yan Zhao, Tingting Chen, Conghua Ji, Yuxin Shang et al. • Experimental Gerontology (2026)

Background: Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.113010

Creating Exercise Spaces in Parks for Older Adults With Fitness, Rehabilitation, and Play Elements: A Review and Perspective

Janet Lok Chun Lee, Rainbow Tin Hung Ho • Gerontology and Geriatric Medicine (2022)

Parks usually create a protective playground space for children to perform physical activity like jumping, running, and climbing. Specific spaces have rarely been created for older adults to perform physical activity in public parks. Now th...

DOAJ Open Access (DOAJ) DOI: 10.1177/23337214221083404

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Yan Cai, Wei Zhu, Chenshu Wu, Yan Jiang • BMC Public Health (2026)

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-026-27192-9

Watching Out for Older Drivers

Samuel Durso • MedEdPORTAL (2006)

Abstract Motor vehicle accidents are the leading cause of injury-related deaths among adults age 65 to 74. This risk for traffic fatalities may triple as the numbers of older drivers increases in the coming years. It is the ethical opinion ...

DOAJ Open Access (DOAJ) DOI: 10.15766/mep_2374-8265.194

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Heterogeneity in Trajectories of Body Mass Index and Their Associations with Mortality in Old Age: A Literature Review

Hiroshi Murayama, Benjamin A. Shaw • Journal of Obesity & Metabolic Syndrome (2017)

This article reviewed studies to investigate the association between trajectories of body mass index (BMI) and mortality among older adults. Investigators conducted a systematic search of published peer-reviewed literature in the PubMed dat...

DOAJ Open Access (DOAJ) DOI: 10.7570/jomes.2017.26.3.181

Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease

Anum Zahra, Maarten van Smeden, Petra J. M. Elders, Jan Festen et al. • BMC Geriatrics (2025)

Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vul...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-025-05721-2

Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty

Sadayuki Ito, Yoshihito Sakai, Kei Ando, Hiroaki Nakashima et al. • Asian Spine Journal (2023)

Study Design Retrospective study. Purpose Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the ca...

DOAJ Open Access (DOAJ) DOI: 10.31616/asj.2022.0120

Investigation of Play Intervention for Dementia (PID) Activities in Addressing Cognitive Domains Reflected in Hong Kong Montreal Cognitive Assessment (HK-MoCA)

Calvin Ka-Fung Lo BHSc, MD, Eric Andrew Yung BSc, MSc, Ka Tat Tsang PhD • Gerontology and Geriatric Medicine (2022)

Background/Objectives: Yee Hong Play Intervention for Dementia (PID) is a community program strengthening East Asians >65 years with dementia in their daily functional activities. We analyzed how PID activities align with Hong Kong Montreal...

DOAJ Open Access (DOAJ) DOI: 10.1177/23337214221130161

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

Leon G. Martens, Jiao Luo, Fleur L. Meulmeester, Nadia Ashrafi et al. • Antioxidants (2020)

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9121280

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Amira Al Balakosy, Mostafa Alfishawy, Omnia Elnabawy, Azza Hassan et al. • Afro-Egyptian Journal of Infectious and Endemic Diseases (2021)

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-1...

DOAJ Open Access (DOAJ) DOI: 10.21608/aeji.2021.72615.1144

Divergent effects of sleep efficiency and sleep medication on episodic memory in mid to late life

Suhani Amin, Dokyung Yoon, Rahul Naveen, Yaseen El-Magharbel et al. • Frontiers in Sleep (2026)

ObjectivesDifferent aspects of sleep quality are known to decline with age, and these changes have been shown to impact performance across multiple cognitive domains. However, despite a growing body of literature, the impact of changes to q...

DOAJ Open Access (DOAJ) DOI: 10.3389/frsle.2025.1691035

Categorias de autocuidado entre pessoas idosas com diabetes: estudo sociopoético [Categories of self-care among older adults with diabetes: a sociopoetic study]

Iraci dos Santos, Renata Gomes Machado Guerra, Leandro Andrade da Silva • Revista Enfermagem UERJ (2015)

Teve-se como objetivo identificar as categorias de autocuidado apresentadas por pessoas idosas com diabetes, considerando suas dimensões física, mental e espiritual. Método sociopoético, aplicando as fases do grupo-pesquisador formado por 1...

DOAJ Open Access (DOAJ) DOI: 10.12957/reuerj.2015.16498

Predictivity of bioimpedance phase angle for incident disability in older adults

Kazuki Uemura, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo et al. • Journal of Cachexia, Sarcopenia and Muscle (2020)

Abstract Background Bioelectrical impedance analysis (BIA)‐derived phase angle is expected to be an efficient prognostic marker of health adverse events with aging as an alternative of muscle mass. We aimed to examine the predictive ability...

DOAJ Open Access (DOAJ) DOI: 10.1002/jcsm.12492

Efeito do Exercício na Funcionalidade, na Depressão e na dor de Idosos Institucionalizados

Alessandra da Silva Oliveira, Claudia Teixeira-Arroyo • Geriatrics, Gerontology and Aging (2024)

Objetivo: Verifi car o efeito de um programa de exercícios físicos funcionais, associados ao componente lúdico, nos sintomas depressivos, na capacidade de realização das atividades da vida diária (AVD) e nos sintomas de dor de idosos instit...

DOAJ Open Access (DOAJ)