Academic Articles & Research Papers

Tissue Biopsy in Infected Foot and Ankle Surgery

Category: Basic Sciences/Biologics Introduction/Purpose: When performing surgical debridement to treat chronically infected orthopaedic cases our unit routinely samples 5 intraoperative specimens for microbiology. Best practice and achievin...

Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma

Background: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors. However, its spatial expression profile and pr...

Context presentation and native conversation structure in large language model responses to escalating suicide risk: a controlled multimodel evaluation

BackgroundLarge language models are increasingly used for informal mental health support, yet their safety during escalating suicide-risk conversations may depend on how prior information is presented. Native multi-turn conversations and re...

Exploring resilience among hospital workers: a Bayesian approach

Background and importanceHealthcare professionals face significant workloads, as their roles are among the most demanding and stressful. Resilience serves as a crucial factor in helping them cope with the challenges encountered in their wor...

"I did not feel the same as before surgery"

This paper examines Audre Lorde’s The Cancer Journals (2020) and her journey post-mastectomy, in relation to José Muñoz’s theory of disidentification, which he discusses in his book Disidentifications: Queers of Color and the Performance of...

Poster 58. Preoperative Corticosteroid Injection History Does Not Influence Meniscal Allograft Transplantation Survivorship or Failure Rates

Objective: Meniscal allograft transplantation (MAT) is a joint-preserving option for patients with symptomatic meniscal deficiency unresponsive to nonoperative care. By restoring tibiofemoral load transmission, MAT can relieve pain, improve...

Prophylactic Absorbable Antibiotic Beads for High-risk, Implant-based Prepectoral Reconstruction

Summary:. Infections are problematic in postmastectomy implant-based reconstruction with infection rates as high as 30%. Strategies to reduce the risk of infection have demonstrated various efficacies. A prolonged course of systemic, oral a...

Non-traumatic Causes of Brown-sequard Syndrome: A Case Series and Clinical Update With Systematic Review

Background and Importance: Brown-Sequard Syndrome (BSS) is a rare neurological condition resulting from a hemisection injury to or unilateral compression on the spinal cord. The common causes of BSS that are amenable to be treated surgicall...

The Role of Artificial Intelligence on Tumor Boards: Perspectives from Surgeons, Medical Oncologists and Radiation Oncologists

The integration of multidisciplinary tumor boards (MTBs) is fundamental in delivering state-of-the-art cancer treatment, facilitating collaborative diagnosis and management by a diverse team of specialists. Despite the clear benefits in per...

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated...

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway

Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damag...

Medico-Legal Applications of the Human Microbiome and Critical Issues Due to Environmental Transfer: A Review

Microbiome has recently seen an increase in its forensic applications. It could be employed to identify a suspect when DNA is not available; it can be used to establish postmortem interval (PMI). Furthermore, it could prove to be fundamenta...

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?

Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considere...

Bacterial Succession in Microbial Biofilm as a Potential Indicator for Postmortem Submersion Interval Estimation

Bacteria acts as the main decomposer during the process of biodegradation by microbial communities in the ecosystem. Numerous studies have revealed the bacterial succession patterns during carcass decomposition in the terrestrial setting. T...

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infe...

ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon p...

Robotic Arthroplasty Clinical and cost Effectiveness Randomised controlled trial (RACER-knee): a study protocol

Introduction Robotic-assisted knee replacement systems have been introduced to healthcare services worldwide in an effort to improve clinical outcomes for people, although high-quality evidence that they are clinically, or cost-effective re...

Analysis of factors affecting the length of stay of patients using clustering and association rules (Case study: Amir al-Momenin Hospital, Maragheh)

One of the major indicators in evaluating the performance of hospitals and their managers is the average length of stay of patients; given the importance of this indicator, the present study has examined the factors affecting the length of ...

Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study

IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the exis...

Operationalizing preparedness: bridging the “Know-Do” gap in Rwanda’s infectious disease policy