Academic Articles & Research Papers

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study...

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key...

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells. We have determined that viral hemagglutinins e...

Ovarian cancer treatment and natural killer cell-based immunotherapy

BackgroundOvarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part of the immune system and have the ability to kill tumor cells directly or participate...

Case Report: A severe case of immunosuppressant-refractory immune checkpoint inhibitor-mediated colitis rescued by tofacitinib

Immune checkpoint inhibitor therapy for cancer treatment can give rise to a variety of adverse events. Here we report a male patient with metastatic melanoma who experienced life-threatening colitis and duodenitis following treatment with i...

Cancer Immunology

This review is a comprehensive account of the current status of tumor immunology, beginning with the identification of human tumor antigens and ending with a summary of clinical applications of what we know about the immunology of tumors....

Uncertainties in the effects of organic aerosol coatings on polycyclic aromatic hydrocarbon concentrations and their estimated health effects

We used the CAM5 model to examine how different particle-bound polycyclic aromatic hydrocarbon (PAH) degradation approaches affect the spatial distribution of benzo(a)pyrene (BaP). Three approaches were evaluated: NOA (no effect of OA coati...

Nanomedicine for Glioblastoma: Cutting-Edge Advances and Persistent Challenges

Cancer is a disorder characterized by the abnormal growth of cells that increases uncontrollably over an extended period of time. Treating cancerous brain tumors remains among the most challenging tasks for researchers, as brain tumors are ...

Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges

Abstract Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and protein cargo which are excreted from cells under a variety of normal and pathological conditions. EVs have garnered substantial research int...

Rezvilutamide in metastatic, hormone-sensitive prostate cancer

The relationship between perceived stress and depression in colorectal cancer patients: the mediating role of illness perception and the moderating role of self-efficacy

BackgroundNumerous studies have demonstrated a close association between perceived stress and depression in colorectal cancer patients; however, the underlying mechanisms remain incompletely understood. This study aims to investigate the im...

Carcinoma In Situ Skip Lesions of the Uterine Corpus in Cervical Squamous Cell Carcinoma: Impact on Target Setting in Radiotherapy.

Topical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment

Actinic keratosis (AK) is a frequent precancerous skin lesion that mostly affects chronically sun-exposed areas. Chronic sun damage leads to various mutations in onco-suppressor and oncogenic genes which cause an uncontrolled proliferation ...

Construction of the cancer patients’ database based on the US National Health and Nutrition Examination Survey (NHANES) datasets for cancer epidemiology research

Abstract Background The US National Health and Nutrition Examination Survey (NHANES) dataset does not include a specific question or laboratory test to confirm a history of cancer diagnosis. However, if straightforward variables for cancer ...

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups. The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain ...

Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer

Recent studies revealed that ethnic differences in mechanistic target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK-1/2) signaling pathways might be associated with the development and progression of different human mal...

A New Strategy for Efficient Screening and Identification of Monoclonal Antibodies against Oncogenic Avian Herpesvirus Utilizing CRISPR/Cas9-Based Gene-Editing Technology

Marek’s disease virus (MDV) is an important oncogenic α-herpesvirus that induces Marek’s disease (MD), characterized by severe immunosuppression and rapid-onset T-cell lymphomas in its natural chicken hosts. Historically, MD is regarded as ...

Molecular MRI Reveals Macrophage-Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer.

Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions

Objective: Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentration in those food products, w...

Ospemifene for vulvar and vaginal atrophy: an overview

The menopause-related decline in estrogen levels leads to an array of genital, sexual, and urinary symptoms collectively known as genitourinary syndrome of menopause. The constellation of symptoms associated with vulvar and vaginal atrophy ...