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The central inflammatory regulator IκBζ: induction, regulation and physiological functions
The central inflammatory regulator IκBζ: induction, regulation and physiological functions
Yanpeng Feng
(Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China)
Zhiyuan Chen
(Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China)
Yi Xu
(Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China)
Yuxuan Han
(Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China)
Xiujuan Jia
(Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, China)
Zixuan Wang
(Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, China)
Nannan Zhang
(Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, China)
Wenjing Lv
(Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China)
Wenjing Lv
(Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, China)
Journal: Frontiers in Immunology
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• Frontiers Media S.A.
• ISSN: 1664-3224
Abstract
IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.
Yanpeng Feng, Zhiyuan Chen, Yi Xu, et al. (2023). "The central inflammatory regulator IκBζ: induction, regulation and physiological functions". Frontiers in Immunology. https://doi.org/10.3389/fimmu.2023.1188253