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Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer

Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology (2023)

Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12957-023-03078-7

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo et al. • Journal of Translational Medicine (2017)

Abstract Background Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic trans...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-017-1327-0

Temperature orchestrates phytoplankton community and environment in mountain stream for enhancing resource use efficiency

Li Ji, Huayong Zhang, Huayong Zhang, Zhongyu Wang et al. • Frontiers in Marine Science (2025)

Warming is a key factor influencing the function of the structure and function of phytoplankton communities. However, the impacts of temperature on phytoplankton resource use efficiency (RUE) in mountain rivers remain poorly understood. Her...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmars.2025.1565858

Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer

Lilla Bűdi, Dániel Hammer, Rita Varga, Veronika Müller et al. • Pathology and Oncology Research (2025)

ObjectivesSpingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circ...

DOAJ Open Access (DOAJ) DOI: 10.3389/pore.2024.1611929

The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients

Steffen Schulz, Jens Haueisen, Karl-Jürgen Bär, Andreas Voss • Frontiers in Neuroscience (2020)

Impaired heart rate- and respiratory regulatory processes as a sign of an autonomic dysfunction seems to be obviously present in patients suffering from schizophrenia. Since the linear and non-linear couplings within the cardiorespiratory s...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2020.00617

Why do emergency department clinicians miss acute aortic syndrome? A case series and descriptive analysis

Rachel McLatchie, Sarah Wilson, Matthew Reed, Francoise Ticehurst et al. • Emergency Care Journal (2023)

Objectives: To understand why the diagnosis of AAS is missed in the ED, and to characterise the presenting features of cases in which a diagnosis of AAS was missed. Methods: A retrospective case series cohort study was performed, identif...

DOAJ Open Access (DOAJ) DOI: 10.4081/ecj.2023.11153

Longevity of dental restorations in Sjogren’s disease patients using electronic dental and health record data

Grace Gomez Felix Gomez, Mei Wang, Zasim A. Siddiqui, Theresa Gonzalez et al. • BMC Oral Health (2024)

Abstract Background Decreased salivary secretion is not only a risk factor for carious lesions in Sjögren’s disease (SD) but also an indicator of deterioration of teeth with every restorative replacement. This study determined the longevity...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12903-024-03957-9

Alpha-Band EEG Modulation as a Potential Aged-Related Biomarker for Biofeedback-Driven Motor–Cognitive Adaptability

Swapno Aditya, Adam Clarke, Lucy Armitage, Wing-Kai Lam et al. • Sensors (2026)

Background: Age-related changes in motor–cognitive function are associated with altered neural adaptability, particularly during tasks requiring integration of cognitive and motor processes. Dual-task paradigms are commonly used to assess s...

DOAJ Open Access (DOAJ) DOI: 10.3390/s26144575

Why did an effective Dutch complex psycho-social intervention for people with dementia not work in the German healthcare context? Lessons learnt from a process evaluation alongside a multicentre RCT

Sebastian Voigt-Radloff, Maud Graff, Myrra Vernooij-Dassen, Rainer Leonhart et al. • BMJ Open (2011)

Background The positive effects of the Dutch Community Occupational Therapy in Dementia programme on patients' daily functioning were not found in a multicentre randomised controlled trial (RCT) in Germany.Objectives To evaluate possible ef...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2011-000094

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López, José M. Romero-Márquez, María D. Navarro-Hortal, César L. Ramirez-Tortosa et al. • Experimental Gerontology (2023)

The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112221

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin et al. • Frontiers in Aging Neuroscience (2021)

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2021.790926

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals et al. • Experimental Gerontology (2023)

Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffeni...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112105

Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial

Gloria Metzner, Lukas Maximilian Horstmeier, Jürgen Bengel, Eva Maria Bitzer et al. • BMC Geriatrics (2023)

Abstract Background In the aging population of Western societies, an increasing number of older adults have multiple chronic diseases. As multifaceted health problems imply the involvement of several healthcare professionals, multimorbid ol...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-03797-2

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

Francesco Valeri, Malena dos Santos Guilherme, Fuqian He, Nicolai M. Stoye et al. • Microorganisms (2021)

Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therap...

DOAJ Open Access (DOAJ) DOI: 10.3390/microorganisms9122548

Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

Ying Li, Ying Li, Na Jia, Xinyue Li et al. • Frontiers in Cardiovascular Medicine (2026)

This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcvm.2026.1753832

Associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older adults

Emi Miki, Risa Kawabata • Cadernos Brasileiros de Terapia Ocupacional (2020)

This study aimed to investigate the associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older Japanese adults by examining the correlations between the Canadian Occup...

DOAJ Open Access (DOAJ) DOI: 10.4322/2526-8910.ctoAO2096

HEART Camp Connect—Promoting adherence to exercise in adults with heart failure with preserved ejection fraction

Windy W. Alonso, Sara E. Bills, Scott W. Lundgren, Steven J. Keteyian et al. • ESC Heart Failure (2025)

Abstract Aims Most adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF)....

DOAJ Open Access (DOAJ) DOI: 10.1002/ehf2.15341

Broca’s biases in modern aphasiology

Silvia Martínez-Ferreiro, Monica I. Norvik, Monica I. Norvik • Frontiers in Human Neuroscience (2026)

Broca’s description of aphemia signals the emergence of aphasiology as a discipline. It also marks the beginning of a long tradition of studies of right-handed patients (“Nous parlons avec l’hémisphère gauche”) with lesions in the inferior ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2026.1783073