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Showing 20 of 208 academic articles

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

Carina Strohmayer, Andrea Klang, Sibylle Kneissl • Frontiers in Veterinary Science (2020)

Squamous cell carcinoma (SCC) is the most common equine sinonasal and feline oral tumour. This study aimed to describe the computed tomographic and histopathological characteristics of equine and feline SCC. Thirteen horses and 10 cats that...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2020.591437

Angiogenesis as a Survival Mechanism in Heartworm Disease: The Role of Fructose-Bisphosphate Aldolase and Actin from <i>Dirofilaria immitis</i> in an In Vitro Endothelial Model

Manuel Collado-Cuadrado, Claudia Alarcón-Torrecillas, Alfonso Balmori-de la Puente, Iván Rodríguez-Escolar et al. • Animals (2024)

Heartworm disease, caused by Dirofilaria immitis, is a vector-borne zoonotic disease, (mainly affecting canids and felids) causing chronic vascular and pulmonary pathology in its early stages, which worsens with parasite load and/or death o...

DOAJ Open Access (DOAJ) DOI: 10.3390/ani14233371

Porang (Amorphophallus oncophyllus) tuber extract improved the histopathological features of diabetic rat (Rattus norvegicus) testicles

Dwi Puspa Sukma Viranda, Rochmah Kurnijasanti, Kadek Rachmawati, Iwan Sahrial Hamid et al. • Ovozoa: Journal of Animal Reproduction (2024)

This study aims to determine the effect of porang (Amorphophallus oncophyllus) tuber extract on the histopathological features of the testicle of alloxan induced rats (Rattus norvegicus). Thirty male rats were randomly divided into six grou...

DOAJ Open Access (DOAJ) DOI: 10.20473/ovz.v13i1.2024.47-57

<i>Vibrio parahaemolyticus</i> Isolates from Asian Green Mussel: Molecular Characteristics, Virulence and Their Inhibition by Chitooligosaccharide-Tea Polyphenol Conjugates

Suriya Palamae, Ajay Mittal, Mingkwan Yingkajorn, Jirakrit Saetang et al. • Foods (2022)

Fifty isolates of Vibrio parahaemolyticus were tested for pathogenicity, biofilm formation, motility, and antibiotic resistance. Antimicrobial activity of chitooligosaccharide (COS)-tea polyphenol conjugates against all isolates was also st...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods11244048

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan et al. • JEADV Clinical Practice (2025)

ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) remains poorly understood at the molecular level, both in the immunocompetent and immunosuppressed population with skin of colour. Data on the diversity of viruses found in cSCC i...

DOAJ Open Access (DOAJ) DOI: 10.1002/jvc2.70142

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication

Zhen-Jia Zhang, Qiang Gao, Xiao-Dong Fang, Zhi-Hang Ding et al. • eLife (2020)

Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood. Here, we characterized a pro-viral role of CCR4 in rep...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.53753

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

EFFECT OF VITAMIN A ON CYCLOSPORINE NEPHROTOXICITY IN UNINEPHRECTOMIZED RATS

Hoda Mohamed, Hazar Yacoub, Heba Ameen, Dureah Sebah • Zagazig Journal of Pharmaceutical Sciences (1997)

The influence of vitamin A (1.5 mg kg-1 body weight) administration for two weeks on cyclosporine A (CsA, 25 mg kg-1 body weight) induced renal dysfunction has been investigated in uninephrectomized and sham nephrectomized rats. Single kidn...

DOAJ Open Access (DOAJ) DOI: https://doi.org/10.21608/zjps.1997.184951

Molecular Dynamics and In Vitro Studies Elucidating the Tunable Features of Reconfigurable Nanodiscs for Guiding the Optimal Design of Curcumin Formulation

Yongxiao Li, Wanting Xu, Xinpei Wang, Ruizhi Lai et al. • Bioengineering (2024)

In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We ...

DOAJ Open Access (DOAJ) DOI: 10.3390/bioengineering11030245

An elderly low-grade fibromyxoid sarcoma patient with early postoperative recurrences and metastases: a case report and literature review

Xiaoyue Zhang, Yongkang Qiu, Jixin Zhang, Zhao Chen et al. • Frontiers in Medicine (2024)

BackgroundLow-grade fibromyxoid sarcoma (LGFMS) is a rare type of soft tissue sarcoma that often involves the deep soft tissue of the extremities and trunk in young and middle-aged adults. It is uncommon in the elderly. Here we discuss a ca...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2024.1172746

Selenium Nanoparticle-Enriched and Potential Probiotic, <i>Lactiplantibacillus plantarum</i> S14 Strain, a Diet Supplement Beneficial for Rainbow Trout

Francisco Yanez-Lemus, Rubén Moraga, Carlos T. Smith, Paulina Aguayo et al. • Biology (2022)

Lactic acid bacteria (LAB), obtained from rainbow trout (Oncorhynchus mykiss) intestine, were cultured in MRS medium and probiotic candidates. Concurrently, producers of elemental selenium nanoparticles (Se0Nps) were selected. Probiotic can...

DOAJ Open Access (DOAJ) DOI: 10.3390/biology11101523

Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice

Clinton M. Hasenour, Arion J. Kennedy, Tomasz Bednarski, Irina A. Trenary et al. • Journal of Lipid Research (2020)

Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control ...

DOAJ Open Access (DOAJ) DOI: 10.1194/jlr.RA119000183

Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach

Michaela Lucas, MD, FRACP, FRCPA, Jillian Kehoe, MHP BSc (Food Science and Technology), Samantha Stiles, PhD, MPH, MID, BSc, Sandra M. Salter, BPharm, Grad Dip Pharm (Hosp), PhD, FPS et al. • Journal of Allergy and Clinical Immunology: Global (2026)

Background: This guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jacig.2026.100784

Childhood Mediterranean Diet Adherence Is Associated with Lower Prevalence of Childhood Obesity, Specific Sociodemographic, and Lifestyle Factors: A Cross-Sectional Study in Pre-School Children

Eleni Pavlidou, Sousana K. Papadopoulou, Olga Alexatou, Gavriela Voulgaridou et al. • Epidemiologia (2023)

Background: The Mediterranean diet (MD) has been related with a decreased probability of overweight/obesity as well as central obesity at all stages of the human life, decreasing the risk of diverse disease states and improving quality of l...

DOAJ Open Access (DOAJ) DOI: 10.3390/epidemiologia5010002

Effect of the students nurses personal pain experience on assessment of pain intensity and selection of appropriate number of pain interventions

P Hasani, S Mohamad-alizadeh, Y Nikiyan, Z Jalili et al. • Journal of Kerman University of Medical Sciences (1994)

This investigation was undertaken to evaluate the " effect of the student nurses" personal pain experience on assessment of pain intensity and selection of appropriate number of pain interventions. Participants in this research were 150 fem...

DOAJ Open Access (DOAJ)

Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration

Ruibang Wu, Leizhen Huang, Qinghong Xia, Zheng Liu et al. • Materials Today Bio (2023)

Intervertebral disc degeneration (IDD) is a major contributing factor to both lower back and neck pain. As IDD progresses, the intervertebral disc (IVD) loses its ability to maintain its disc height when subjected to axial loading. This fai...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.mtbio.2023.100731

THERAPEUTIC EFFECT OF PACLITAXEL LOADED ON GOLD NANOPARTICLES IN TREATMENT OF INDUCED ORAL SQUAMOUS CELL CARCINOMA

Fatma H. El-Didi, Marwa M. Essawy, Sagy L. Asar, Sahar M. El-Sheikh et al. • Alexandria Dental Journal (2019)

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with high mortality rate. Conventional treatment strategies have improved but remain far from optimal. Cancer research is focused on improving cance...

DOAJ Open Access (DOAJ) DOI: 10.21608/adjalexu.2019.57569

Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma

Yawei Sun, Shuai Wang, Xingwei Zhang, Zhuhao Wu et al. • Biomolecules (2021)

Background: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors. However, its spatial expression profile and pr...

DOAJ Open Access (DOAJ) DOI: 10.3390/biom11121842

Unveiling Insights into the Whole Genome Sequencing of <i>Mycobacterium</i> spp. Isolated from Siamese Fighting Fish (<i>Betta splendens</i>)

Nguyen Dinh-Hung, Samuel Mwakisha Mwamburi, Ha Thanh Dong, Channarong Rodkhum et al. • Animals (2024)

This study aims to genomically elucidate six isolates of rapidly growing non-tuberculous mycobacteria (RGM) derived from Siamese fighting fish (Betta splendens). These isolates had previously undergone phenotypic and biochemical characteriz...

DOAJ Open Access (DOAJ) DOI: 10.3390/ani14192833

Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission

Cornelia Geßner, Alena Krüger, Lars P. Folkow, Wilfrid Fehrle et al. • Frontiers in Molecular Neuroscience (2022)

The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of mo...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2022.877349