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Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia

Zhengzhong Luo, Zhenlong Du, Yixin Huang, Tao Zhou et al. • mSystems (2024)

ABSTRACTMetabolic maladaptation in dairy cows after calving can lead to long-term elevation of ketones, such as β-hydroxybutyrate (BHB), representing the condition known as hyperketonemia, which greatly influences the health and production ...

DOAJ Open Access (DOAJ) DOI: 10.1128/msystems.00023-24

Alleviation effect of glycyrrhetinic acid on zearalenone-induced reproductive toxicity in replacement gilts

Li-Tao Che, Li-Tao Che, Ahmed H. El-Sappah, Ahmed H. El-Sappah et al. • Frontiers in Veterinary Science (2025)

IntroductionThis study investigated whether glycyrrhetinic acid (GA) can alleviate the reproductive toxicity of Zearalenone (ZEN) in replacement gilts.MethodsEighty Landrace × Yorkshire gilts were randomly assigned to four dietary groups: c...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2025.1636738

A Novel MRAC Scheme for Output Tracking

Tingting Tian, Xiaorong Hou, Fang Yan • Mathematics (2022)

This paper puts forward a novel output feedback model reference adaptive control (MRAC) scheme for solving an adaptive output tracking problem. The proposed control scheme only needs a scalar function to be updated online, which decreases t...

DOAJ Open Access (DOAJ) DOI: 10.3390/math10142384

Further Results on a Curious Arithmetic Function

Long Chen, Kaimin Cheng, Tingting Wang • Journal of Mathematics (2020)

Let p be an odd prime number and n be a positive integer. Let vpn, N∗, and Q+ denote the p-adic valuation of the integer n, the set of positive integers, and the set of positive rational numbers, respectively. In this paper, we introduce an...

DOAJ Open Access (DOAJ) DOI: 10.1155/2020/1894162

Does English proficiency matter? Testing its moderating role in the TAM for AI-enhanced MOOC adoption in vocational education

Shuhua Hou, Xianhe Liu, Xiaoqing Shen, Chenyun Zhang et al. • Frontiers in Psychology (2026)

This study investigates whether English proficiency moderates core Technology Acceptance Model (TAM) pathways in the context of AI-enhanced English MOOCs for vocational students. Drawing on an extended TAM that links Perceived Ease of Use (...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyg.2026.1772129

Exploring the formation mechanism of off-flavor of irradiated yak meat based on metabolomics

Qia Wang, Kai Dong, Yongyan Wu, Fengping An et al. • Food Chemistry: X (2022)

Irradiation's effects on quality, volatile compounds, and differential metabolites of yak meat were studied. Irradiation dose at 3 kGy had no effect on yak meat quality, however irradiation dose at 5 kGy resulted in yak meat quality deterio...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fochx.2022.100494

Rap GTPase Interactor: A Potential Marker for Cancer Prognosis Following Kidney Transplantation

Qiang Fu, Qiang Fu, Qiang Fu, Fan Yang et al. • Frontiers in Oncology (2019)

Post-transplant (post-Tx) kidney cancer has become the second-highest cause of death in kidney recipients. Late diagnosis and treatment are the main reasons for high mortality. Further research into early diagnosis and potential treatment i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2019.00737

Association between Higher Blood Pressure and Risk of Diabetes Mellitus in Middle-Aged and Elderly Chinese Adults

Xue Yang, Jian Chen, An Pan, Jason H.Y. Wu et al. • Diabetes & Metabolism Journal (2020)

BackgroundTo examine the prospective association between higher blood pressure (BP) and risk of type 2 diabetes mellitus (T2DM) in middle-aged and elderly Chinese adults.MethodsA total of 9,642 middle-aged and elderly Chinese adults (≥45 ye...

DOAJ Open Access (DOAJ) DOI: 10.4093/dmj.2019.0081

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology (2026)

BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2026.1784245

Predictive Value of Serum Cytokeratin 19 Level for the Feasibility of Conserving Ovaries in Endometrial Cancer

Jie Xu, Jie Xu, Can Chen, Can Chen et al. • Frontiers in Medicine (2021)

Objective: To determine the predictive value of cytokeratin 19 (CK19) for evaluating the safety of ovarian preservation in patients with endometrial cancer (EC).Methods: Five hundred and seventeen EC patients hospitalized from November 2010...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2021.670109

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

Kecheng Li, Kecheng Li, Xiaoli Zhou, Xiaoli Zhou et al. • Frontiers in Endocrinology (2024)

IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β pe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2024.1278477

Integrated Dentist–Nurse Collaborative Care Model for Caries Management in China

Jiaohong Liu, Haohao Wang, May Lei Mei, Chloe Meng Jiang et al. • Dentistry Journal (2026)

Dental caries, as a common chronic disease with high global prevalence, has undergone a paradigm shift from a traditional treatment-oriented model to a management approach focused on controlling caries risk factors while implementing person...

DOAJ Open Access (DOAJ) DOI: 10.3390/dj14070430

Association of maternal metabolic risk factors with offspring body mass index (BMI) trajectories in early childhood: a retrospective cohort study

Wei Song, Xiao Yang, Liu Yang, Yan Ren et al. • BMJ Open (2025)

Objective This study aimed to identify body mass index (BMI) growth trajectories from birth to 24 months of age and examine the independent and additive effects of four maternal metabolic risk factors, namely prepregnancy BMI, the rate of g...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2024-088641

Gut Microbiota and Metabolome Description of Antibiotic-Treated Neonates From Parturients With Intrauterine Infection

Huitao Li, Lei Fu, Xueyu Chen, Heng Xu et al. • Frontiers in Cellular and Infection Microbiology (2022)

Intrauterine infection is linked to adverse pregnancy outcomes in pregnant women. Neonates from parturients with intrauterine infection are usually treated with antibiotics, but their gut microbiota and metabolome are seldom studied. In thi...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2022.817832

Evaluating Urban–Rural Disparity of Public Facilities Provision in Chengdu–Chongqing: An Equity Index Approach with Multi-Source Data

Xuan Liu, Youxin Qian, Guohui Zhou, Guangyu Xu et al. • Systems (2026)

Urban–rural public facility disparity is a systemic challenge that reflects dysfunctional feedback loops within and across social and technical subsystems. Traditional administrative-unit-based analyses cannot capture such systemic alignmen...

DOAJ Open Access (DOAJ) DOI: 10.3390/systems14080903

Exogenous gibberellin and spermidine optimize flowering time and ornamental quality by regulating antioxidant capacity, soluble nutrient levels, and endogenous hormone balance of Primula forbesii

Zhuo Lv, Keying Ding, Wenbao Ma, Wenyu Li et al. • Scientia Horticulturae (2026)

Primula forbesii Franch. is a biennial ornamental species increasingly used in flower landscape design, potted displays, and cut flower production. Nevertheless, studies on its flowering regulation remain limited. This study investigated th...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.scienta.2026.114731

Efficacy of integrative medicine using Yinhua-based herbal granules on herpangina: A Bayesian network meta-analysis of randomized controlled trials

Yongcheng Sheng, Yuhui Zhang, Qin Wang, Qi Hong et al. • Phytomedicine Plus (2022)

Background: Different Traditional Chinese Medicine (TCM) in the format of granules, such as Kanggan Granules (KangGs), Kouyanqing Granules (KouGs), Lianhua Qingwen Granules (LQGs), Qingkailing Granules (QGs) and Xiao'er Qingjie Granules (XQ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.phyplu.2022.100351