Academic Articles & Research Papers

P2′ Site Scanning of Snake Kunitz-Type Toxin Analogue BF9-N17H with Unique P1 Site Histidine Highlights Novel XIa Inhibitory Peptides Without Plasmin Inhibitory Activity

Kunitz-type peptides from venomous and blood-sucking animals represent an important natural molecular resource for anticoagulant development towards XIa, a new target for antithrombotic drug discovery. However, the plasmin-inhibitory activi...

β-Cell Death in Diabetes: Past Discoveries, Present Understanding, and Potential Future Advances

β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and potential future advances in our understanding of the m...

Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity

Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemio...

Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study

Background The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease ...

Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke

Background: Ischemic stroke is one of the serious complications of diabetes. Non-coding RNAs are established as promising biomarkers for diabetes and its complications. The present research investigated the expression profiles of serum TUG1...

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-spec...

MOLECULAR BIOLOGY OF THE MYCOBACTERIA

The molecular biology of the mycobacteria is poised at the threshold of making major contributions to the understanding of the biochemistry and pathogenic mechanisms involved in mycobacterial infections.The application of molecular biology ...

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration. Interleukin-22 (IL-22) is a pl...

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from <i>Talaromyces amestolkiae</i>: Potential Antiproliferative and Neuroprotective Effect of These Molecules

Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed...

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism underlying the ULK complex assembly have yet to be ...

P415: TARGETED 3RD-GENERATION (NANOPORE) SEQUENCING REVEALS MANY NOVEL CIRCULAR RNAS OF THE APOPTOSIS-RELATED BCL2L12 GENE, EXPRESSED IN HUMAN CELLS FROM ACUTE MYELOID LEUKEMIA AND MYELODYSPLASTIC SYNDROMES

Molecular biology and biochemistry of the endothelins

Molecular Biology and Biotechnology

One of the exciting aspects of being involved in the field of molecular biology is the ever-accelerating rate of progress, both in the development of new methodologies and the practical applications of these methodologies. This popular text...

Molecular Biology of the Gene

The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA doub...

Graphene Quantum Dots Modified with Metformin/Co(II) as Efficient Oxidation Catalyst

While one of the valuable approaches to obtaining a heterogeneous catalyst is supporting them on a high surface area supports, the strategy mainly suffers from the low number of chelating agents on most of the supports to grip the metal cat...

Externally triggered drug delivery systems

Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential for clinical disease management, offe...

Nitrogen-Doped Mesoporous Carbon Microspheres by Spray Drying-Vapor Deposition for High-Performance Supercapacitor

Nitrogen-doped mesoporous carbon microspheres have been successfully synthesized via a spray drying-vapor deposition method for the first time, using commercial Ludox silica nanoparticles as hard templates. Compared to freeze-drying and air...

Physics, chemistry and biology of functional nanostructures II

Enhancing the oxidative cleavage of vicinal diols on Fe-ZSM-5 catalysts with hierarchical porosity

The oxidative cleavage of biomass-derived vicinal diols holds significant potential for producing valuable renewable carboxylic acids. Fe-ZSM-5 zeolite is a highly effective catalyst for this reaction using mild reaction conditions; however...

Nanotechnology

Human dreams and imagination often give rise to new science and technology. Nanotechnology, a 21st-century frontier, was born out of such dreams. Nanotechnology is defined as the understanding and control of matter at dimensions between 1 a...