Huiyang Hu
(Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA)
Prabhakar Busa
(Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA)
Yue Zhao
(School of Computer Science, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, China)
Chao Zhao
(Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA; Center for Convergent Biosciences and Medicine, University of Alabama, Tuscaloosa, AL, 35487, USA; Corresponding author. Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA.)
Journal: Smart Materials in Medicine
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• KeAi Communications Co., Ltd.
• ISSN: 2590-1834
Abstract
Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential for clinical disease management, offering appealing features like enhanced patient adherence through the elimination of needles and medication reminders. Additionally, it facilitates personalized medicine by granting patients control over the timing, dosage, and duration of drug release. Moreover, it enables precise drug delivery to targeted locations where external stimuli are applied. Advances in materials science, nanotechnology, chemistry, and biology have been pivotal in driving the development of these systems. This review presents an overview of the progress in research on drug release systems responsive to external stimuli, such as light, ultrasound, magnetic fields, and temperature. It discusses the construction strategies of externally triggered drug delivery systems, the mechanisms governing triggered drug release, and their applications in disease management.