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Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli

Yasushi Hirasawa, Aiko Muramatsu, Yoshio Suzuki, Tadashi Nagamatsu • Journal of Pharmacological Sciences (2006)

To elucidate the involvement of cyclooxygenase (COX) in degradation of aggregated protein in diabetic glomeruli, we used streptozotocin (STZ)-induced diabetic mice and aggregated bovine serum albumin (a-BSA) as a model protein. There was a ...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.FPJ06010X

Heat transfer by three types of hot pack and its implication on the flexibility of the lower back: a randomized, controlled trial

Paulina Fuentes-León, Natalia Jara-Poblete, Pía Bastías-Sánchez, Kaio Fernando Vitzel et al. • Fisioterapia e Pesquisa (2016)

ABSTRACT The use of hot pack is a common superficial thermotherapy strategy and one of its benefits is the increase of muscle flexibility. However, there is a lack of information about the effects of the heat pack alone, without being used ...

DOAJ Open Access (DOAJ) DOI: 10.1590/1809-2950/15088923022016

The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases

Bongani Sannyboy Lukhele, Kokoette Bassey, Bwalya Angel Witika • Current Issues in Molecular Biology (2023)

Medicinal plants have been utilized to treat a variety of conditions on account of the bioactive properties that they contain. Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeabilit...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb45120624

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura et al. • Journal of Pharmacological Sciences (2013)

Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicit...

DOAJ Open Access (DOAJ) DOI: 10.1254/jphs.13012SC

Fumaric acid regulates morphine tolerance in bone cancer pain through spinal MrgC receptor modulation

Sijie Liu, Minghao Tang, Jing Zhao, Lulu Zhang et al. • Pakistan Journal of Pharmaceutical Sciences (2026)

Background: Bone cancer pain (BCP) represents a debilitating complication that profoundly impacts patient quality of life and predisposes to psychological comorbidities, including depression and anxiety. Objectives: To investigate the effec...

DOAJ Open Access (DOAJ) DOI: 10.36721/PJPS.2026.39.8.233.1

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Teerapat Rodboon, Sasithorn Sirilun, Seiji Okada, Ryusho Kariya et al. • Research in Pharmaceutical Sciences (2020)

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-5362.297852

Characterization of low-nitrogen quantum diamond for pulsed magnetometry applications

Jiashen Tang, Jiashen Tang, Connor A. Roncaioli, Andrew M. Edmonds et al. • Frontiers in Quantum Science and Technology (2025)

Ensembles of nitrogen-vacancy (NV) centers in diamond are versatile quantum sensors with broad applications in the physical and life sciences. The concentration of neutral substitutional nitrogen ([Ns0]) strongly influences NV electronic sp...

DOAJ Open Access (DOAJ) DOI: 10.3389/frqst.2025.1701548

Controlled Plasmonic Coupling in Silver Nanoplate Dimers for Enhanced Plasmonic Sensing

Lucrezia Catanzaro, Marcello Condorelli, Mario Pulvirenti, Luisa D’urso et al. • Nanomaterials (2026)

Noble metal nanostructures provide versatile platforms for light manipulation through localized surface plasmon resonances (LSPRs). Among them, triangular silver nanoplates (AgNPTs) exhibit strong field-enhancement and spectral tunability, ...

DOAJ Open Access (DOAJ) DOI: 10.3390/nano16080486

Implementing an Adaptive Thrust Distribution Algorithm on the Robust Control System for Serial Split-Hull Underwater Vehicles

Vishakh S. Kumar, Prabhu Rajagopal • IEEE Access (2022)

This paper discusses designing and implementing an adaptive thrust distribution algorithm on the already robust control system for serial split-hull underwater vehicles to maximise operational efficiency. Split-hull underwater vehicles are ...

DOAJ Open Access (DOAJ) DOI: 10.1109/ACCESS.2022.3223118

Diagnosis of winter precipitation types using the spectral bin model (version 1DSBM-19M): comparison of five methods using ICE-POP 2018 field experiment data

W. Bang, J. T. Carlin, K. Kim, A. V. Ryzhkov et al. • Geoscientific Model Development (2025)

Winter precipitation types (WPTs) are controlled by many factors, including thermodynamic and microphysical processes. Therefore, realistically simulating interactions between precipitation particles and the atmosphere is important when dia...

DOAJ Open Access (DOAJ) DOI: 10.5194/gmd-18-3559-2025

Investigating the cost of mechanized unpaved road maintenance operations in Uganda

Andrew Moses Obeti, Lawrence Muhwezi, John Muhumuza Kakitahi, Chris Bic Byaruhanga • Transportation Research Interdisciplinary Perspectives (2024)

Force Account Mechanism (FAM) is the predominant road maintenance system in Uganda’s local government setup and a similar, though slightly different approach, is used in some large private sector agriculture plantations. With the Uganda Roa...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.trip.2024.101135

Research and practice of key technologies for landslide dam development and utilization—A case in Hongshiyan landslide Dam Water Conservancy Project

Zongliang Zhang, Xueming Wu, Enshang Xiao, Ning He et al. • River (2023)

Abstract Based on the emergency rescue, the subsequent disposal, and the development and utilization projects of the Hongshiyan Landside Dam in Ludian, Yunnan, China, research has been conducted on key technical issues facing the developmen...

DOAJ Open Access (DOAJ) DOI: 10.1002/rvr2.51

Selenium Nanoparticle-Enriched and Potential Probiotic, <i>Lactiplantibacillus plantarum</i> S14 Strain, a Diet Supplement Beneficial for Rainbow Trout

Francisco Yanez-Lemus, Rubén Moraga, Carlos T. Smith, Paulina Aguayo et al. • Biology (2022)

Lactic acid bacteria (LAB), obtained from rainbow trout (Oncorhynchus mykiss) intestine, were cultured in MRS medium and probiotic candidates. Concurrently, producers of elemental selenium nanoparticles (Se0Nps) were selected. Probiotic can...

DOAJ Open Access (DOAJ) DOI: 10.3390/biology11101523