Academic Articles & Research Papers

Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity

Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemio...

The Role of Mast Cells and Their Potential as a Therapeutic Target For Neuroinflammation

Sarah Adriana Scuderi,1 Rossella Basilotta,2 Laura Cucinotta,2 Alessio Ardizzone,3 Emanuela Esposito21Genetics and Pharmacogenetics Unit, ‘Gaetano Martino’ University Hospital, Messina, Italy; 2Department of Chemical, Biological, Pharmaceut...

Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study

Background The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease ...

Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke

Background: Ischemic stroke is one of the serious complications of diabetes. Non-coding RNAs are established as promising biomarkers for diabetes and its complications. The present research investigated the expression profiles of serum TUG1...

High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia

Abstract Background Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity, respectively. There has been no information on the status of co-infections of tuberculosis a...

The Molecular Biology of Coronaviruses

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration. Interleukin-22 (IL-22) is a pl...

S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets

Base on the sequence of S genes, which encode spike proteins, we previously identified three different types (North American, S INDEL, and S large-DEL types) of porcine epidemic diarrhea virus (PEDV) that have re-emerged in Japan since 2013...

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected indiv...

Beginning at the ends: telomeres and human disease [version 1; referees: 4 approved]

Studies of rare and common illnesses have led to remarkable progress in the understanding of the role of telomeres (nucleoprotein complexes at chromosome ends essential for chromosomal integrity) in human disease. Telomere biology disorders...

Innovative green niosomal piperlongumine as a novel topical treatment for dermatophytosis in guinea pigs model

Abstract Dermatophytosis is a common superficial fungal infection that affects many people worldwide. Although various species of dermatophytes respond to common antifungal drugs, the recently identified Trichophyton indotineae isolates hav...

Externally triggered drug delivery systems

Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential for clinical disease management, offe...

Prevalence and patterns of prescription errors and potential drug-drug interactions in Yemeni healthcare facilities: a cross-sectional study.

Post-diagnostic support for dementia in the UK: mapping access, delivery and gaps in provision.

Effect of aging on marginal and internal adaptation of bulk-fill resin composites with different viscosities in class II restorations.

Prevalence and clinical outcomes of malnutrition in hospitalized patients: a real-world study using a stepwise screening-assessment pathway.

Design Considerations for a Distributed Low-Cost Air Quality Sensing System for Urban Environments in Low-Resource Settings

With rapid urbanization, hazardous environmental exposures such as air, noise, plastic, soil and water pollution have emerged as a major threat to urban health. Recent studies show that 9 out of 10 people worldwide breathe contaminated air ...

Relationship between grief and coping strategies among nurses dealing with patient deaths: a descriptive, cross-sectional, correlational study

Abstract Background Nurses often face significant emotional distress and grief when dealing with patient deaths, especially in acute hospital settings. Despite extensive literature offering guidance on nursing practices for providing optima...

Effect of angiotensin-converting enzyme gene polymorphism at the results of losartan use in the patients with type 2 diabetes mellitus

Poniatowskaya T. Yu. Effect of angiotensin-converting enzyme gene polymorphism at the results of losartan use in the patients with type 2 diabetes mellitus. Journal of Education, Health and Sport. 2015;5(3):55-61. ISSN 2391-8306. DOI: 10.52...

Plasmodium vivax Transmission in Africa.

Malaria in sub-Saharan Africa has historically been almost exclusively attributed to Plasmodium falciparum (Pf). Current diagnostic and surveillance systems in much of sub-Saharan Africa are not designed to identify or report non-Pf human m...