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Showing 20 of 404 academic articles

From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases

Kaixuan Chen, Longjun Chen, Yizhong Ma, Siqi Chen et al. • Frontiers in Pharmacology (2025)

The skeletal system is an important support structure in the human body, and its homeostatic state is highly relevant to the development of a wide range of orthopaedic diseases. The search for key regulatory factors associated with skeletal...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2025.1614542

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu et al. • Cellular & Molecular Biology Letters (2025)

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

DOAJ Open Access (DOAJ) DOI: 10.1186/s11658-025-00690-1

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury

Alessandro L. Gallina, Urszula Rykaczewska, Robert C. Wirka, Robert C. Wirka et al. • Frontiers in Cardiovascular Medicine (2021)

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An im...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcvm.2021.655869

A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss

Diego Pozzer, Ersilia Varone, Alexander Chernorudskiy, Silvia Schiarea et al. • Redox Biology (2019)

Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to human SELENON-related myopathies. SelenoN knockout (KO) mouse limb muscles, however, are protected from the disease, and display no major alt...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.redox.2018.10.017

Tumor probability mapping of fluorescence intensity during image-guided surgery of head and neck cancer

Akhilesh M Wodeyar, Sherin James, Benjamin B. Kasten, Nicolaus D. Knight et al. • Scientific Reports (2026)

Abstract Achieving negative surgical margins remains a critical determinant of local recurrence and survival in head and neck cancer (HNC) surgery. Current intraoperative margin assessment techniques, including frozen section analysis, suff...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-026-56078-4

Effect of stress ball use before cholecystectomy surgery on surgical fear, anxiety and comfort of patients: a randomized controlled trial

Hatice Merve Alptekin, Seval Ulubay, Seda Cansu Yeniğün Akbulut • BMC Nursing (2025)

Abstract Background Thinking about surgery generally causes fear and anxiety among patients. These negative feelings may affect the healing process. This study aimed to investigate the effects of a stress ball on surgical fear, anxiety and ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12912-025-04057-x

Rheumatoid Arthritis and Cardiovascular Risk: Retrospective Matched-Cohort Analysis Based on the RECORD Study of the Italian Society for Rheumatology

Lisa Argnani, Anna Zanetti, Anna Zanetti, Greta Carrara et al. • Frontiers in Medicine (2021)

Background: Rheumatoid arthritis (RA) is associated with an increase in cardiovascular (CV) risk. This issue maybe not only explained by a genetic component, as well as by the traditional CV risk factors, but also by an underestimation and ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2021.745601

Impact of preoperative insomnia on poor postoperative pain control after elective spine surgery and the modified Calgary postoperative pain after spine surgery (MCAPPS) score

Michael M.H. Yang, MD, MSc, MBiotech, Jay Riva-Cambrin, MD, MSc, Jonathan Cunningham, MD, MSc, Steven Casha, MD, PhD • North American Spine Society Journal (2023)

Background: Approximately 30% to 64% of patients experience inadequate pain control following spine surgery. The Calgary postoperative pain after spine surgery (CAPPS) score was developed to identify this subset of patients. The impact of p...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xnsj.2023.100261

Spontaneous anastomosis of esophageal atresia without esophageal stricture formation: A case report

S. Tan Tanny, S.E. Newman, M. Safe, W.J. Teague • Journal of Pediatric Surgery Case Reports (2025)

Introduction: Spontaneous esophago-esophageal fistulization is a reported phenomenon in cases of complex esophageal atresia, however, short and long-term complications are common, including stricture formation. Case presentation: A male twi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.epsc.2025.102972

Outcomes of Peripheral Vascular Interventions in Select Patients With Lower Extremity Acute Limb Ischemia

Elica Inagaki, Alik Farber, Jeffrey A. Kalish, Mohammad H. Eslami et al. • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (2018)

BackgroundContemporary data on patients presenting with acute limb ischemia (ALI), who are selected for treatment with endovascular peripheral vascular interventions (PVI), are limited. Our study examined outcomes following endovascular PVI...

DOAJ Open Access (DOAJ) DOI: 10.1161/JAHA.116.004782

LASIK Surgery

Megan Yu • Voices in Bioethics (2020)

Photo by Scott Van Daalen on Unsplash INTRODUCTION LASIK surgery, one of the most common elective procedures worldwide, aims to decrease or eliminate the need to wear glasses or contact lenses by reshaping the cornea’s curvature to re...

DOAJ Open Access (DOAJ)

Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia

Wang Yang, Ling Zou, Qianqian Wu, Lu Yang et al. • Journal of Materials Science: Materials in Medicine (2026)

Abstract Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, ...

DOAJ Open Access (DOAJ) DOI: 10.1007/s10856-026-07062-x

Baseline Characteristics, Risk Factors and Etiology of Heart Failure Among Patients Hospitalized at a Teaching Hospital in Somalia: Cross-Sectional Study

Farah Yusuf Mohamud M, Jeele MOO, Cetinkaya O, Goitom Sereke S et al. • Research Reports in Clinical Cardiology (2022)

Mohamed Farah Yusuf Mohamud,1 Mohamed Osman Omar Jeele,1 Osman Cetinkaya,1 Senai Goitom Sereke,2 Felix Bongomin,3 Mohamed AM Ahmed4– 6 1Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 2School of Medicine, Colleg...

DOAJ Open Access (DOAJ)

Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8+ T cells towards the center of human lung tumors

Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild et al. • OncoImmunology (2023)

Lung cancer is a leading cause of cancer-related death worldwide. Despite recent advances in tissue immunology, little is known about the spatial distribution of tissue-resident lymphocyte subsets in lung tumors. Using high-parameter flow c...

DOAJ Open Access (DOAJ) DOI: 10.1080/2162402X.2023.2233402

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Yanpeng Feng, Zhiyuan Chen, Yi Xu, Yuxuan Han et al. • Frontiers in Immunology (2023)

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2023.1188253