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Changes in daily living dependency and incident depressive symptoms among older individuals: findings from four prospective cohort studies

Hongwei Liu, Juxiang Yang, Gang Song, Minheng Zhang et al. • BMJ Mental Health (2025)

Background With rapid population ageing, depressive symptoms in older adults have become a pressing public health concern. While functional dependency is a known risk factor, the impact of changes in dependency over time remains unclear.Obj...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjment-2025-301749

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López, José M. Romero-Márquez, María D. Navarro-Hortal, César L. Ramirez-Tortosa et al. • Experimental Gerontology (2023)

The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112221

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin et al. • Frontiers in Aging Neuroscience (2021)

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2021.790926

Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice

Yuta Doshida, Shinichi Hashimoto, Sadahiro Iwabuchi, Yuka Takino et al. • Scientific Reports (2023)

Abstract Senescent cells are predicted to occur and increase in animal tissues with aging. However, senescent cells in the tissues of aged animals remain to be identified. We refer to the marker genes to identify senescent cells in tissues ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-41352-6

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience (2026)

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2026.1783807

Local, collaborative, stepped, and personalized care management for older people with chronic diseases – results from the randomized controlled LoChro-trial

Gloria Metzner, Lukas Maximilian Horstmeier, Jürgen Bengel, Eva Maria Bitzer et al. • BMC Geriatrics (2023)

Abstract Background In the aging population of Western societies, an increasing number of older adults have multiple chronic diseases. As multifaceted health problems imply the involvement of several healthcare professionals, multimorbid ol...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12877-023-03797-2

The burden and determinants of cognitive impairment among individuals with chronic diseases in Ethiopia: A systematic review and meta-analysis

Addisu Getie, Melaku Bimerew, Mihretie Gedfew, Baye Tsegaye Amlak et al. • Archives of Gerontology and Geriatrics Plus (2025)

Introduction: Cognitive impairment is a medical condition caused by neurodegeneration, marked by a gradual decline in neurological, motor, psychological, and cognitive domain functions, as well as daily activities. It primarily affects indi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2025.100171

Types of Skin Afferent Fibers and Spinal Opioid Receptors that Contribute to Touch-Induced Inhibition of Heart Rate Changes Evoked by Noxious Cutaneous Heat Stimulation

Nobuhiro Watanabe, Mathieu Piché, Harumi Hotta • Molecular Pain (2015)

Background In anesthetized rats and conscious humans, a gentle touch using a soft disc covered with microcones (with a texture similar to that of a finger), but not with a flat disc, inhibits nociceptive somatocardiac reflexes. Such an inhi...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12990-015-0001-x

Nutritional status, literacy, and risk factors of malnutrition in the population over 50 years of age - findings from the SHARE project

Tereza Vágnerová, Olga Dvořáčková, Eva Topinková • Clinical Nutrition Open Science (2024)

Summary: Background & Aims: The transition from middle age to old age (from adults aged 50–55 years to older seniors aged 75–80 years) represents a critical period in terms of changes in body composition, i.e., increase in body fat per...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nutos.2024.01.006

Procedural Results and Long-Term Outcomes of Percutaneous Coronary Intervention for in-Stent Restenosis Chronic Total Occlusion Compared with de novo Chronic Total Occlusion

Tang G, Zheng N, Yang G, Li H et al. • International Journal of General Medicine (2021)

Guodong Tang, Naixin Zheng, Guojian Yang, Hui Li, Hu Ai, Ying Zhao, Fucheng Sun, Huiping Zhang Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences,...

DOAJ Open Access (DOAJ)

Diffuse hypertrophic obstructive cardiomyopathy complicated by apical ventricular aneurysm and excessive left ventricular trabeculation: a case report

Ying Li, Ying Li, Na Jia, Xinyue Li et al. • Frontiers in Cardiovascular Medicine (2026)

This article reports a rare case of diffuse hypertrophic obstructive cardiomyopathy complicated with left ventricular apical aneurysm and excessive trabeculation. Genetic testing of the patient revealed a heterozygous variant of the MYBPC3 ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcvm.2026.1753832

Associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older adults

Emi Miki, Risa Kawabata • Cadernos Brasileiros de Terapia Ocupacional (2020)

This study aimed to investigate the associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older Japanese adults by examining the correlations between the Canadian Occup...

DOAJ Open Access (DOAJ) DOI: 10.4322/2526-8910.ctoAO2096

Broca’s biases in modern aphasiology

Silvia Martínez-Ferreiro, Monica I. Norvik, Monica I. Norvik • Frontiers in Human Neuroscience (2026)

Broca’s description of aphemia signals the emergence of aphasiology as a discipline. It also marks the beginning of a long tradition of studies of right-handed patients (“Nous parlons avec l’hémisphère gauche”) with lesions in the inferior ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2026.1783073

A review of studies that used B mode ultrasound to estimate age-related changes in anterior thigh skeletal muscle thickness across the adult lifespan

Isobel Jacob, Gareth Jones, Peter Francis, Mark I Johnson • Archives of Gerontology and Geriatrics Plus (2024)

Background: The purpose of this review was to synthesise and determine the age-related change per annum in muscle thickness of the anterior thigh across the adult lifespan. Methods: Electronic databases (PubMed, SPORTDiscus and MEDLINE) wer...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2024.100037

Cloud Radiative Feedback to the Large‐Scale Atmospheric Circulation Greatly Reduces Monsoon‐Season Wet Bias Over the Tibetan Plateau in Climate Modeling

Jiarui Liu, Kun Yang, Dingchi Zhao, Peili Wu et al. • Geophysical Research Letters (2024)

Abstract Over‐estimation of summer precipitation over the Tibetan Plateau (TP) is a well‐known and persistent problem in most climate models. This study demonstrates the impact of a Gaussian Probability Density Function cloud fraction schem...

DOAJ Open Access (DOAJ) DOI: 10.1029/2024GL109180

Rock Magnetism and Magnetic Fabric Study of the Icelandite and Rhyodacite Long Volcanic Sequence at Mauna Kuwale, Wai’anae Volcano, Oahu, Hawaii, USA

Emilio Herrero-Bervera, Mario Moreira • Geosciences (2023)

In order to understand further the emplacement (i.e., volcanic growth) of 22 Icelandite and 3 Rhyodacite cooling units in one of the long volcanic sequences known as Mauna Kuwale of the Wai’anae volcano (ca. 3.3 Ma), Oahu Hawaii we have con...

DOAJ Open Access (DOAJ) DOI: 10.3390/geosciences13040114

Rapakivi K‐Feldspar Megacrysts in Monzogranitic Porphyry: Evidence for Magma Recharge and Mush Rejuvenation

Wang Li, Xuxuan Ma, Roberto Weinberg, Liang Qiu et al. • Geochemistry, Geophysics, Geosystems (2025)

Abstract The formation, storage, and evolution of granitic magmas are fundamental processes driving the growth of continental crust. While traditionally attributed to crystal fractionation in high‐melt fraction magma chambers, the model inv...

DOAJ Open Access (DOAJ) DOI: 10.1029/2025GC012435

Uncovering the Tradeoffs and Synergies of Ecosystem Services in Mining Landscapes: Spatiotemporal and Factor Detection Perspective

Jiao Pan, Tao Chen, Antonio Plaza • IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2025)

Revealing the spatial-temporal evolution and interactions of ecosystem services (ESs) in mining area is critical for sustainable environmental management. The temporal and spatial characteristics and changing trends of six ESs in Yuzhong mi...

DOAJ Open Access (DOAJ) DOI: 10.1109/JSTARS.2025.3586637