Academic Articles & Research Papers

Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study

Background The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease ...

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-spec...

Graphs in molecular biology

Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology. We d...

Molecular Biology of the Cell

An introduction to the essentials of the molecular biology of the cell would easily fill this book. Instead I shall focus on one set of problems in molecular biology that Francis Crick, one of the discoverers of the DNA double helix, has ter...

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration. Interleukin-22 (IL-22) is a pl...

Molecular biology and biochemistry of the endothelins

Computational Molecular Biology

In one of the first major texts in the emerging field of computational molecular biology, Pavel Pevzner covers a broad range of algorithmic and combinatorial topics and shows how they are connected to molecular biology and to biotechnology....

Innovative green niosomal piperlongumine as a novel topical treatment for dermatophytosis in guinea pigs model

Abstract Dermatophytosis is a common superficial fungal infection that affects many people worldwide. Although various species of dermatophytes respond to common antifungal drugs, the recently identified Trichophyton indotineae isolates hav...

Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis

Atherosclerosis (AS) is a disorder of large and medium-sized arteries; it consists in the formation of lipid-rich plaques in the intima and inner media, whose pathophysiology is mostly driven by inflammation. Currently available interventio...

Elastic modulus of β-Ga2O3 nanowires measured by resonance and three-point bending techniques

Due to the recent interest in ultrawide bandgap β-Ga2O3 thin films and nanostructures for various electronics and UV device applications, it is important to understand the mechanical properties of Ga2O3 nanowires (NWs). In this work, we inv...

Externally triggered drug delivery systems

Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential for clinical disease management, offe...

Nanotechnology

The emergence of nanoscience portends a revolution in technology that will soon impact virtually every facet of our technological lives. Yet there is little understanding of what it is among the educated public and often among scientists an...

Nanotechnology for the biologist

Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1- to 100-nanometers range...

Nanotechnology and medicine

Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medi...

A ROADMAP FOR A COMPUTATIONAL THEORY OF THE VALUE OF INFORMATION IN ORIGIN OF LIFE QUESTIONS

Information plays a critical role in complex biological systems. Complex systems like immune systems and ant colonies co-ordinate heterogeneous components in a decentralized fashion. How do these distributed decentralized systems function? ...

Synthesizing distributed systems

In system synthesis, we transform a specification into a system that is guaranteed to satisfy the specification. When the system is distributed, the goal is to construct the system's underlying processes. Results on multi-player games imply...

A systems-level energetic framework for conscious processing: energetic organization as a constraint on large-scale neural integration

Conscious processing is associated with coordinated interactions among distributed neural systems, yet the biological constraints that enable and sustain large-scale neural integration remain incompletely understood. Contemporary theories e...

Time, clocks, and the ordering of events in a distributed system

The concept of one event happening before another in a distributed system is examined, and is shown to define a partial ordering of the events. A distributed algorithm is given for synchronizing a system of logical clocks which can be used ...

Constructing distributed systems in Conic

The Conic environment provides a language-based approach to the building of distributed systems which combines the simplicity and safety of a language approach with the flexibility and accessibility of an operating systems approach. It prov...

A calculus for access control in distributed systems

We study some of the concepts, protocols, and algorithms for access control in distributed systems, from a logical perspective. We account for how a principal may come to believe that another principal is making a request, either on his own...