Academic Articles & Research Papers

ROS/Enzyme Dual-Responsive Drug Delivery System for Targeted Colorectal Cancer Therapy: Synergistic Chemotherapy, Anti-Inflammatory, and Gut Microbiota Modulation

Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, driven by chronic inflammation, gut microbiota dysbiosis, and complex tumor microenvironment interactions. Current therapies are limited by systemic toxicit...

Distinct monocyte phenotypes are associated with peri-coronary inflammation in persons with and without HIV and without cardiovascular disease.

Differential Associations of Seven Circulating Complement Proteins with Heart Failure: A Single-Center Cross-Sectional Study.

Integrated Transcriptomic Analysis and Experimental Validation Identify ATF3 as a Mesangial Cell-Associated Candidate Regulator in IgA Nephropathy.

Etiology of Hunner Lesions: Linking Immune Dysregulation and Chronic Inflammation in Interstitial Cystitis/Bladder Pain Syndrome.

LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment.

Preoperative systemic inflammation response index and 12-month endoscopic recurrence after endoscopic sinus surgery in chronic rhinosinusitis with nasal polyps: association and incremental predictive performance in a same-institution, two-campus cohort.

Ameliorative Effects and Underlying Molecular Mechanisms of Nootkatone in DSS-Induced Ulcerative Colitis in Mice.

SerRS2 Identifies an Inflamed-Exhausted Hepatocellular Carcinoma Phenotype with Enhanced DNA-Sensing and Increased Anti-PD-1 Responsiveness.

Keratinocyte TMEM79 protects early life epidermal homeostasis and restrains STING-dependent skin inflammation.

Stress-induced helicase DHX36 controls neuroinflammation.

A human rheumatoid arthritis bone-cartilage interface organoid recapitulates bone, cartilage, and immune interactions.

Infant-onset mevalonate kinase deficiency with a previously unreported MVK c.827 A > G (p.Glu276Gly) variant presenting as suspected incomplete kawasaki disease with marked hyperinflammation: clinical response to firsekibart and systematic evidence synthesis.

Short-chain fatty acids and intestinal macrophage immunometabolism in metabolic syndrome: mechanisms and implications for chronic low-grade inflammation.

NRF2: sensing stress, shaping immunity - keeping inflammation quiet and antigens out of sight.

Mediating effect of inflammation on the association between glucocorticoid response-related polymorphism and metabolic syndrome in patients with schizophrenia: Evidence from the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) cohort.

Inflammation and delayed oral calcium supplementation: Associations with milk yield, reproduction, and herd removal in multiparous Holstein dairy cows.

Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective.

Microglia and neuroinflammation: An in-depth analysis from functional diversity to disease mechanisms.

Restructuring the gut microbiota in obesity: molecular mechanisms linking dysbiosis to systemic inflammation and therapeutic opportunities.