Structure Determination Using Spectroscopic Methods

Overview & Synopsis

This note
focuses on how spectroscopic techniques can be integrated to determine the
structure of unknown molecules. It starts off with an overview of the
electromagnetic spectrum and basic 1H NMR, moving on to much advanced discussion
about how NMR can be combined with other methods such as IR, UV, and mass
spectrometry for an overall structural analysis. It goes over chemical shifts of
protons, coupling constants, and the use of 2D NMR for obtaining detailed
structural information. Other topics discussed include multinuclear NMR, dynamic
NMR and conformational, as well as chemical exchange rates measurement. This
note is perfect for students and researchers who want to use several
spectroscopic methods in the determination of the structure of a compound.